International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 33Review Article
Review ArticlePublished: 10 Dec 2020
Tehzeeb T, Dhanabalan D
pp. 417-422 · DOI: 10.5530/ijpi.2020.4.74Vol. 10, Issue 4 (2020)Recent progress in drug discovery in past decades reduced the high level of pain experienced due to infectious diseases by humans. A significant impact has been made on developing novel antimicrobial agents but is failin…
Review ArticlePublished: 10 Dec 2020
Pitchaimuthu Pandian
pp. 423-429 · DOI: 10.5530/ijpi.2020.4.75Vol. 10, Issue 4 (2020)Heparin is used as anticoagulant for long period and also other activities both experimentally and clinically. The heparin is prepared by many methods namely enzymatic hydrolysis, chemical hydrolysis by removing the anti…
Original Article
Original ArticlePublished: 10 Dec 2020
Amit Vinayak Asati, Kishor Sahebrao Salunkhe, Machindra Jairam Chavan, Ravindra Bhausaheb Chintamani, Rudra Pratap Singh
pp. 430-436 · DOI: 10.5530/ijpi.2020.4.76Vol. 10, Issue 4 (2020)Background: Solubility is an important physico-chemical factor affecting absorption of drug and its therapeutic effectiveness. One of the major problems responsible for the low turnout in the development of new molecular…
Original ArticlePublished: 10 Dec 2020
Ekramul Haque, Mohd Aamir Bin Riyaz, Sriram Shankar, Saqib Hassan
pp. 437-444 · DOI: 10.5530/ijpi.2020.4.77Vol. 10, Issue 4 (2020)Objectives: The aim of this study was to isolate a potent biosurfactant producing bacterium and characterize the produced biosurfactant for its application in pharmaceutical, petrochemical, cosmetic and food industry. Me…
Original ArticlePublished: 10 Dec 2020
Johnson Stephin, Koland Marina
pp. 445-451 · DOI: 10.5530/ijpi.2020.4.78Vol. 10, Issue 4 (2020)Introduction: Helicobacter pylori infection is strongly associated with chronic gastritis and duodenal ulcers which can benefit from gastro retentive delivery of clarithromycin. Objectives: The objective of this study wa…
Original ArticlePublished: 10 Dec 2020
S Agarwal, G Gautam
pp. 452-455 · DOI: 10.5530/ijpi.2020.4.79Vol. 10, Issue 4 (2020)Background: The present investigation was held to develop vesicular ethosomal gel system for anti-hypertensive drug atorvastatin. Atorvastatin is a HMG-CoA reeducates inhibitor and utilized for minimizing cholesterol lev…
Original ArticlePublished: 10 Dec 2020
Prasad Suhas Kshirsagar, Darshana Sanjay Mote, Shriniwas Pramod Patil
pp. 456-459 · DOI: 10.5530/ijpi.2020.4.80Vol. 10, Issue 4 (2020)Introduction: Andrographis paniculata is medicinal plant of family Acanthaceae, consists of bitter principles and traditionally used in treatment of several gastrointestinal diseases. To mask its bitter taste, it could b…
Original ArticlePublished: 10 Dec 2020
Garima Jain, Umesh K Patil
pp. 460-465 · DOI: 10.5530/ijpi.2020.4.81Vol. 10, Issue 4 (2020)Objectives: The objective of the present study was to formulate, characterize and evaluate herbal formulations of Evolvulus alsinoides and Convolvulus pluricaulis against scopolamine-induced behavioral disturbances for A…
Original ArticlePublished: 10 Dec 2020
Zoya Shprakh
pp. 466-470 · DOI: 10.5530/ijpi.2020.4.82Vol. 10, Issue 4 (2020)Background: Nitrosoureas are chemotherapeutic alkylating agents, widely used in the treatment of malignant diseases. One of them (streptozotocin) is the standard for the therapy of neuroendocrine tumours. We synthesised …
Original ArticlePublished: 10 Dec 2020
Naseeb Basha Shaik, Divya Shakelli, Lakshmi PK, Basava Rao VV
pp. 471-478 · DOI: 10.5530/ijpi.2020.4.83Vol. 10, Issue 4 (2020)Objectives: The objective of the present study was to improve the absorption of dolutegravir sodium by developing oral proliposomal formulation. Methods: Proliposomal formulations were prepared by film deposition on carr…
Original ArticlePublished: 10 Dec 2020
Pankaj Bhatt, Suruchi Singh, Satish Kumar Sharma, Sani Rabiu
pp. 479-485 · DOI: 10.5530/ijpi.2020.4.84Vol. 10, Issue 4 (2020)Objectives: Aim of the present research work is to prepared rapid mouth dissolving film of frovatriptan Succinate. Methods: Rapid Dissolving Film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 an…
Original ArticlePublished: 10 Dec 2020
Rathna Kumarasamy, Padavala Navyaka, Ekramul Haque
pp. 486-491 · DOI: 10.5530/ijpi.2020.4.85Vol. 10, Issue 4 (2020)Objectives: In this study, bioengineered AgNPs (silver nanoparticles) from Spirulina platensis was used to counter the biofilm mediated virulence by Vibrio parahemolyticus. Methods: AgNPs were synthesized from crude Spir…
Original ArticlePublished: 10 Dec 2020
Amit Verma, Neetu Sachan, Kamla Pathak, Anurag Verma
pp. 492-499 · DOI: 10.5530/ijpi.2020.4.86Vol. 10, Issue 4 (2020)Objectives: Natural polysaccharides are increasingly being used for diverse applications in drug delivery such as controlled release of drugs owing to their wide availability, renewability, biodegradability and biosafety…
Original ArticlePublished: 10 Dec 2020
Yeramanchi Sarah Sujitha, Yallamali Indira Muzib
pp. 500-505 · DOI: 10.5530/ijpi.2020.4.87Vol. 10, Issue 4 (2020)Objectives: The objective of the present study was to increase the solubility of poorly soluble drug hesperidin and to increase the efficacy of the drug by loading hesperidin in emulsomal topical gel. Methods: Hesperidin…
Original ArticlePublished: 10 Dec 2020
Pathuri Raghuveer, Avula Prameela Rani
pp. 506-511 · DOI: 10.5530/ijpi.2020.4.88Vol. 10, Issue 4 (2020)Aim: Self nano-emulsifying drug delivery system (SNEDDS) of candesartan cilexetil was explored to enhance its oral bioavailability. SNEDDS has tremendous potential in enhancing oral bioavailability of poorly aqueous solu…
Original ArticlePublished: 10 Dec 2020
Balamurugan Krishnan, Kirtimaya Mishra
pp. 512-518 · DOI: 10.5530/ijpi.2020.4.89Vol. 10, Issue 4 (2020)Objectives: This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti- diabetic drugs (sitagliptin and metformin) in bulk and pharmaceutical formulations …
Original ArticlePublished: 10 Dec 2020
İshak Erik, Gözde Kılıç, Sevde Seher Yaylı, Gülşah Yılmaz, Kamil Coşkunçelebi, Nurettin Yaylı
pp. 519-525 · DOI: 10.5530/ijpi.2020.4.90Vol. 10, Issue 4 (2020)Background: The present work was aimed to carry out volatile component analyzes in Vaccinium arctostaphlyos L., V. uliginosum L., V. vitis-idaea L. and V. myrtillus L leaf growing at different altitudes of the East Black…
Original ArticlePublished: 10 Dec 2020
Atchuta Ramakrishna Gudapati, Srinivasarao Pakalapati, Chidananda Swamy Rumalla, Benarji Patrudu Tammina
pp. 526-530 · DOI: 10.5530/ijpi.2020.4.91Vol. 10, Issue 4 (2020)Objectives: Analytical methods are necessary for the field of pharmaceuticals to discover the drug, determination of drugs and metabolites in biological matrices. The present study aimed to develop liquid chromatography-…
Original ArticlePublished: 10 Dec 2020
Novel Development of RP-HPLC Method to Quantify Amoxicillin, Omeprazole and Rifabutin in Combination
Rama Kumar Kandula, Raja Sundararajan
pp. 531-536 · DOI: 10.5530/ijpi.2020.4.92Vol. 10, Issue 4 (2020)Objectives: Helicobacter pylori infections are liable for most of the ulcers in the stomach and small intestinal. Talicia capsules was approved to be prescribed for the Helicobacter pylori infections. These capsules have…
Original ArticlePublished: 10 Dec 2020
HK Sundeep Kumar, Sujit Kumar Sahu, Jitendra Debata
pp. 537-541 · DOI: 10.5530/ijpi.2020.4.93Vol. 10, Issue 4 (2020)Objectives: To develop a novel ultra-performance liquid chromatographic technique for the estimation of alectinib in a API and tablet. Methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1 x 50…