International Journal of Pharmaceutical Investigation · Archive
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In this issue
Review Article
Review ArticlePublished: 7 Oct 2014
Thushara Bindu Dudala, Prasanna Raju Yalavarthi, Harini Chowdary Vadlamudi, Jyotsna Thanniru, Gowri Yaga, Naga Lakshmi Mudumala, Vivek Kumar Pasupati
pp. 149-155 · DOI: 10.4103/2230-973X.143112Vol. 4, Issue 4 (2014)Both hydrophilic and lipophilic therapeutics can be delivered successfully into deep and peripheral tissues such as cerebrospinal fl uid and central nervous system by encapsulating them with crystalline lipids as liposph…
Original Research Article
Original Research ArticlePublished: 7 Oct 2014
Swati Gupta, Shailendra Kumar Singh, Priti Girotra
pp. 156-163 · DOI: 10.4103/2230-973X.143113Vol. 4, Issue 4 (2014)Introduction: Silymarin is one of the best known hepatoprotective drugs, which is obtained from the seeds of Silybum marianum L., Family: Asteraceae or Compositae. The plant has traditionally been used for centuries as a…
Original Research ArticlePublished: 7 Oct 2014
Raad A. Kaskoos
pp. 164-173 · DOI: 10.4103/2230-973X.143114Vol. 4, Issue 4 (2014)Introduction: Management of ocular surface disease by conventional formulation is limited by poor residence of drug at cul-de-sac of eye. To overcome this limitation, prolonged released mucoadhesive chitosan (CS)–dextran…
Original Research ArticlePublished: 7 Oct 2014
Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion
Dasharath M. Patel, Sweeti P. Patel, Chhagan N. Patel
pp. 174-182 · DOI: 10.4103/2230-973X.143116Vol. 4, Issue 4 (2014)Introduction: Fast dissolving tablet containing domperidone ternary solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. Materials and Methods: Binary and ternary solid dis…
Original Research ArticlePublished: 7 Oct 2014
J. Jayasree, S. Sivaneswari, G. Hemalatha, N. Preethi, B. Mounika, S. Vasudeva Murthy
pp. 183-188 · DOI: 10.4103/2230-973X.143118Vol. 4, Issue 4 (2014)Objectives: The objective of the present work was to formulate and to characterize controlled release matrix tablets of losartan potassium in order to improve bioavailability and to minimize the frequency of administrati…
Original Research ArticlePublished: 7 Oct 2014
Chukwuma O. Agubata, Salome A. Chime, Franklin C. Kenechukwu, Ifeanyi T. Nzekwe, Godswill C. Onunkwo
pp. 189-194 · DOI: 10.4103/2230-973X.143120Vol. 4, Issue 4 (2014)Introduction: The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide (HCTZ) by the formulation and characterization of HCTZ solid lipid microparticles (SLMs)…
Original Research ArticlePublished: 7 Oct 2014
Parul Jaiswal, Geeta Aggarwal, Sasidharan Leelakumari Harikumar, Kashmir Singh
pp. 195-206 · DOI: 10.4103/2230-973X.143123Vol. 4, Issue 4 (2014)Objectives: Self-microemulsifying drug delivery system (SMEDDS) and solid-SMEDDS of telmisartan was aimed at overcoming the problems of poor solubility and bioavailability. Methodology: The formulation strategy included …
Original Research ArticlePublished: 7 Oct 2014
Poluri Koteswari, Suvarnala Sunium, Puttugunta Srinivasababu, Govada Kishore Babu, Pinnamraju Durga Nithya
pp. 207-214 · DOI: 10.4103/2230-973X.143125Vol. 4, Issue 4 (2014)Introduction: Epilepsy is a serious neurological disorder. Lamotrigine is an alternative to lithium for the treatment of epilepsy, and its oral bioavailability is 98%; however, its poor aqueous solubility hinders its ora…
Original Research ArticlePublished: 7 Oct 2014
Suresh G Killedar, Ashwini B Nale, Harinath N More, Sameer J Nadaf, Anuja A Pawar, Umarfarukh S Tamboli
pp. 215-225 · DOI: 10.4103/2230-973X.143128Vol. 4, Issue 4 (2014)Introduction: Present work, is an effort toward exploring the potential of Cassia fi stula Linn. seed gum as an extended release polymer and laxative. While, C. fi stula pulp polymer has evaluated as suspending agent. Ma…
Original Research ArticlePublished: 7 Oct 2014
Jayesh K. Jethava, Gaurang K. Jethava
pp. 226-232 · DOI: 10.4103/2230-973X.143131Vol. 4, Issue 4 (2014)Introduction: The eye is an interesting organ. The tear fl ow and blinking refl ex maintains a good environment and removes foreign material from the eye. Several polymeric systems have been used to fabricate ocular inse…