International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 48Review Article
Review ArticlePublished: 11 Jun 2026
Toijam Sanjeev Lyngdoh, Dollyca Ningombam, Thangal Yumnamcha, Maibam Damayanti Devi
pp. 770-778 · DOI: 10.5530/ijpi.20260019Vol. 16, Issue 3 (2026)Radiation-induced toxicity poses significant challenges in radiation therapy, nuclear incidents, industrial, and other occupational applications. This review investigates the potentiality of natural bioactive compounds a…
Review ArticlePublished: 11 Jun 2026
Madiha Sultana, Tushar Verma, Anju Jose, Swetha Ramesh, Sonia Singh
pp. 779-787 · DOI: 10.5530/ijpi.20260028Vol. 16, Issue 3 (2026)Monkeypox, an Orthopoxvirus genus zoonotic ailment, has resurfaced as a global public health issue, with outbreaks in 2022 and 2024 highlighting alterations in its epidemiology and transmission dynamics. This narrative s…
Review ArticlePublished: 11 Jun 2026
Yash Manoj Salve, Sukeshini Bharat Lote, Mayur Rajeshwar Dandekar, Isha Anil Mirzapure
pp. 788-799 · DOI: 10.5530/ijpi.20260507Vol. 16, Issue 3 (2026)Stimuli-Responsive Drug Delivery Systems (SRDDS), also regarded as smart” drug delivery systems, have emerged as a vital element of precision pharmaceutics, with the ability of a spatiotemporally controlled therapeutic r…
Review ArticlePublished: 11 Jun 2026
Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju, Thoppalada Yunus Pasha
pp. 800-807 · DOI: 10.5530/ijpi.20260556Vol. 16, Issue 3 (2026)Epilepsy is a chronic brain condition that affects more than 65 million people worldwide, with 30% of patients unable to control seizures, despite progress in Antiepileptic Drugs (AEDs). This article exploring the histor…
Review ArticlePublished: 11 Jun 2026
Lokeshvar Ravikumar, Ramaiyan Velmurugan, Grandhi Surendra, P Sivasubramanian, Konatham Teja Kumar Reddy, Kanaka Durga Hanumanthu, R Venkateswararao, Dhanush Bellapu, Ramenani Hari Babu, Medishetti Swetha
pp. 808-825 · DOI: 10.5530/ijpi.20260603Vol. 16, Issue 3 (2026)The hepatic organ plays a vital role in maintaining the body's homeostasis by facilitating intricate biochemical reactions. Hepatic impairment, a pervasive condition in diverse liver disorders, poses considerable challen…
Review ArticlePublished: 11 Jun 2026
Vuyyala Himachand, Tummadapu Bhavya, Uyyuri Kusuma, Prathi Sriya, Ravilisetty Pranavi, Nagineni Sudarshan Rao
pp. 826-835 · DOI: 10.5530/ijpi.20260159Vol. 16, Issue 3 (2026)The pulsatile drug delivery system is based on a reservoir system consisting of a drug-containing effervescent core and which are coated with a swelling membrane and a polymeric coating which is insoluble but water perme…
Review ArticlePublished: 11 Jun 2026
Harikumar Selvaraj, Santhini Gopalakrishnan
pp. 836-842 · DOI: 10.5530/ijpi.20260035Vol. 16, Issue 3 (2026)Sirtuin 1 (SIRT1) is a metabolic regulator implicated in insulin signaling, inflammation, and mitochondrial function. Several SIRT1 gene polymorphisms have been linked to Type 2 Diabetes Mellitus (T2DM) and its complicat…
Review ArticlePublished: 11 Jun 2026
Kaniga Pandi, Binoy Varghese Cheriyan, Dharshan Murali, Nesayan Boobalan, Jeevitha Harikrishnan, Deepshikaa Kannan, Lini Priyadharshini Christopher Jebaraj, Shamyuktha Munuswamy, Shagul Hameed Manaksha, Sriharan Sekar, Vimal Palaniraja, Naresh Sivagnanam, Revathy Kumar
pp. 843-858 · DOI: 10.5530/ijpi.20260055Vol. 16, Issue 3 (2026)Bone-drug interactions represent a critical yet often under recognized domain within clinical pharmacology due to their long-term implications on skeletal integrity. The human skeletal system relies on a tightly regulate…
Review ArticlePublished: 11 Jun 2026
Teng Ma
pp. 859-862 · DOI: 10.5530/ijpi.20260112Vol. 16, Issue 3 (2026)Schizophrenia is a chronic and severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits, imposing profound burdens on patients, families, and healthcare systems worldwide.…
Review ArticlePublished: 11 Jun 2026
Isha Anil Mirzapure, Manish Deshmukh, Manjusha Bhange, Yash Manoj Salve, Mayur Rajeshwar Dandekar
pp. 863-879 · DOI: 10.5530/ijpi.20260500Vol. 16, Issue 3 (2026)The delayed access to innovative medicinal products such as orphan drugs and biologics and mRNA vaccines and advanced therapy medicinal products ATMPs occurs in numerous developing nations because of disjointed regulator…
Review ArticlePublished: 11 Jun 2026
Vishal Kulkarni, R T Sai Kumari, Sanjunath Satteppa Muchandi, Sanatkumar Bharamu Nyamagoud, H M Nanjappaiah, Vishwanath Jagadevappa Hooli, Sangamesh Sharanbasappa Tadkal, Prasad Nijaguni Bali
pp. 880-884 · DOI: 10.5530/ijpi.20261067Vol. 16, Issue 3 (2026)Parkinson's Disease (PD) is a common neurodegenerative disorder. It is defined by a progressive loss of dopamine neurons in the substantia nigra pars compacta and neurodegeneration, which eventually results in a decrease…
Review ArticlePublished: 11 Jun 2026
Durga Pani Kumar Anumolu, Bugga Veena, Syed Sara Afreen, Jahnavi Bandla, KNV. Chenchu Lakshmi, Veera Shakar Pulusu
pp. 885-891 · DOI: 10.5530/ijpi.20260116Vol. 16, Issue 3 (2026)Background: In vitro assays play a crucial part in evaluating the metabolic fate of drug candidates and understanding the activity of drug-metabolizing enzymes. Materials and Methods: Model systems including Hepatocytes,…
Review ArticlePublished: 11 Jun 2026
Pragati Jain, Abhinav Srivastava, Anurag Verma, Urvashi Saxena
pp. 892-909 · DOI: 10.5530/ijpi.20260186Vol. 16, Issue 3 (2026)The stepwise overview of the regulatory approval pathway for new drugs in India, focusing on requirements and key forms mandated by the NDCT Rules, 2019. It explains how new drugs are legally defined and categorized, set…
Review ArticlePublished: 11 Jun 2026
Mohammed Tarique, Abdulmajeed Abdulghani Abdulmajeed Sindi, Nawal Helmi, Qamre Alam
pp. 910-918 · DOI: 10.5530/ijpi.20260225Vol. 16, Issue 3 (2026)Breast Cancer (BC) is the leading cause of mortality in the majority of women around the globe. It stands as one of the most common types of cancer after non-melanoma skin cancer. Contemporary oncology distinguishes BC u…
Review ArticlePublished: 11 Jun 2026
Saritha Medapati, Vandana Rani Malakar, Naga Mallikarjun Pyda, Prasanthi Pakalapati, Sheik Jakir Hussain Mustaq, Seetha Devi Alla
pp. 1018-1024 · DOI: 10.5530/ijpi.20260098Vol. 16, Issue 3 (2026)Background: To formulate and assess floating bilayer tablets of Tizanidine Hydrochloride (TZN) intended to extend gastric retention and for sustained release of the drug. Materials and Methods: Six bilayered floating tab…
Review ArticlePublished: 11 Jun 2026
Lakshmipriya Bachina, Kanagala Anusha, Niveditha Pallerla
pp. 1039-1045 · DOI: 10.5530/ijpi.20260086Vol. 16, Issue 3 (2026)Aim/Background: Generative Artificial Intelligence (Generative AI or Gen AI) is a subset of Artificial Intelligence that produces multimedia content, including text, images, stories, videos, music, and other digital arti…
Review ArticlePublished: 11 Jun 2026
Emmanuel Madugula, Niranjan Patra, Tinku Baidya
pp. 1098-1103 · DOI: 10.5530/ijpi.20260132Vol. 16, Issue 3 (2026)Background: Isotretinoin, a retinoid derivative of vitamin A, is widely used for the treatment of severe recalcitrant acne, reduces sebum production, suppresses sebaceous gland activity, and exhibits potent anti-inflamma…
Review ArticlePublished: 11 Jun 2026
Pradeep Kumar, Vaibhav Rastogi
pp. 1158-1169 · DOI: 10.5530/ijpi.20260288Vol. 16, Issue 3 (2026)Background: Apixaban is a novel oral anticoagulant widely used in the treatment and prevention of thromboembolic disorders. However, oral administration is associated with delayed onset of action and inaccurate gastroint…
Original Article
Original ArticlePublished: 11 Jun 2026
Rajeshwari Vijaykumar Kamat, Srivarshini Srinivasan, Asath Bharathy Parasuraman
pp. 919-926 · DOI: 10.5530/ijpi.20260570Vol. 16, Issue 3 (2026)Background: Cheminformatics has emerged as a powerful tool in early-phase drug discovery, enabling the efficient evaluation of bioactive compounds from natural sources. Vateria indica (Sarjarasa), a medicinal plant used …
Original ArticlePublished: 11 Jun 2026
Vinayak Madhukar Gaware, Kiran Bhausaheb Dhamak, Vikas Damu Kunde, Mayur Trimbak Gaikar
pp. 927-936 · DOI: 10.5530/ijpi.20260056Vol. 16, Issue 3 (2026)Aim/Background: This study focuses on the synthesis and evaluation of novel pyrimidine derivatives as potential anti-inflammatory agents. Materials and Methods: The compounds were synthesized via a two-step process: cond…