International Journal of Pharmaceutical Investigation · Archive
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In this issue
Original Research Article
Original Research ArticlePublished: 17 Mar 2015
Nilesh Kulkarni, Pravin Wakte, Jitendra Naik
pp. 73-80 · DOI: 10.4103/2230-973X.153381Vol. 5, Issue 2 (2015)Introduction: The aim of the present work was to develop controlled release, fl oating and mucoadhesive beads of glipizide by using the polyionic complexation technique. Plasma half-life of glipizide being 2–4 h was sele…
Original Research ArticlePublished: 17 Mar 2015
Y Deepthi, T. E. Gopalakrishna Murthy
pp. 81-86 · DOI: 10.4103/2230-973X.153382Vol. 5, Issue 2 (2015)Most of the currently available drugs are having poor water solubility and suffer from low oral bioavailability. One of the most promising approaches to deliver such insoluble drugs is by dissolving it in lipids, liquids…
Original Research ArticlePublished: 17 Mar 2015
K. Viveksarathi, K. Kannan
pp. 87-91 · DOI: 10.4103/2230-973X.153383Vol. 5, Issue 2 (2015)Background: Nanoscale solid lipid particles of rasagiline mesylate (RM) were fabricated by microemulsion technique. The nanoscale particle must be sterile for intravenous administration, and several approaches are availa…
Original Research ArticlePublished: 17 Mar 2015
Priya Patel, Abhishek Dave, Amit Vasava, Paresh Patel
pp. 92-100 · DOI: 10.4103/2230-973X.153385Vol. 5, Issue 2 (2015)Objective: The purpose of this study was to prepare sustained release tablet of moisture sensitive drug like Ranitidine Hydrochloride for treatment of gastroesophageal reflux disease along with the improvement of moistur…
Original Research ArticlePublished: 17 Mar 2015
Suryadevara Vidyadhara, Reddyvallam Lankapalli Sasidhar, Thalamanchi Balakrishna, Malapolu Santha Vardhan
pp. 101-106 · DOI: 10.4103/2230-973X.153387Vol. 5, Issue 2 (2015)Aim: The present study deals with the formulation of fast dissolving fi lms of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to prov…
Original Research ArticlePublished: 17 Mar 2015
Sona S. Chaudhary, Hetal K. Patel, Punit B. Parejiya, Pragna K. Shelat
pp. 107-113 · DOI: 10.4103/2230-973X.153389Vol. 5, Issue 2 (2015)Introduction: Hypertension is a disease which shows circadian rhythm in the pattern of two peaks, one in the evening at about 7pm and other in the early morning between 4 am to 8 am. Conventional therapies are incapable …
Original Research ArticlePublished: 17 Mar 2015
Jyotsana R. Madan, Kiran T. Pawar, Kamal Dua
pp. 114-120 · DOI: 10.4103/2230-973X.153390Vol. 5, Issue 2 (2015)Low aqueous solubility is a major problem faced during formulation development of new drug molecules. Lurasidone HCl (LRD) is an antipsychotic agent specially used in the treatments of schizophrenia and is a good example…