International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 30Review Article
Review ArticlePublished: 5 Dec 2024
Tanu Raj Dulal, Deepak Kumar Jha, Saroj Kumar Sah, Mehdi Fathima
pp. 1-9 · DOI: 10.5530/jphi.20251571Vol. 15, Issue 1 (2024)Dendritic Cells (DCs) play a pivotal role in the immune system, acting as sentinels that capture, process and present antigens to T cells, thus initiating and regulating immune responses. Activation of DCs stands at the …
Review ArticlePublished: 5 Dec 2024
Puja Ganeshrao Maldhure, Anita Wanjari, Kirti Naharwal
pp. 10-18 · DOI: 10.5530/jphi.20251739Vol. 15, Issue 1 (2024)Histamine is found in a variety of bodily fluids, platelets, leucocytes, basophils and mast cells in the human body. Mast cells and circulating basophiles store the majority of histamine. Moreover, histamine functions as…
Review ArticlePublished: 5 Dec 2024
Deepika Dyapenahalli Umesh, Purushotham Karadigere Nagaraj, Likhith Kumar Karadigere, Madhu Bommenahalli Krishnegowda, Thoppalada Yunus Pasha
pp. 19-29 · DOI: 10.5530/jphi.20250020Vol. 15, Issue 1 (2024)Cancer is one of the world’s most prevalent causes of death; there is a constant need to find novel treatment medications with increased efficacy and reduced adverse effects. Cancer is a complex group of diseases charact…
Review ArticlePublished: 5 Dec 2024
Fahad Raad Salim Altalib, Omar A Hamid
pp. 30-48 · DOI: 10.5530/jphi.20250057Vol. 15, Issue 1 (2024)In recent decades targeted drug delivery has obtained a significant interest for its ability to enhance therapeutic efficacy and reduce side effects of the drugs. Among them, colon-targeting drug delivery systems have be…
Review ArticlePublished: 5 Dec 2024
Kaviya Suresh, Devasena Srinivasan, Venkatesan Palanivel, Anbarasan Balu
pp. 49-56 · DOI: 10.5530/jphi.20250082Vol. 15, Issue 1 (2024)Nanocochleates, lipid-based nanostructures inspired by the cochlea’s spiral structure, have developed as talented candidates for advanced drug delivery systems and therapeutic applications. Their special design, which co…
Review ArticlePublished: 5 Dec 2024
Mahalakshmi Devaraji, Lokeshvar Ravikumar
pp. 57-66 · DOI: 10.5530/jphi.20251769Vol. 15, Issue 1 (2024)In recent years, biomedical research has resulted in innovative methods for precisely altering genomes, advancing personalized diagnostics and therapeutics through genetic engineering. The Clustered Regularly Interspaced…
Review ArticlePublished: 5 Dec 2024
Hellen Yayra Dzoagbe, Anup Sanjay Shende, Mujibhullah Sheikh, Mrunal Deshmukh
pp. 67-77 · DOI: 10.5530/jphi.20251862Vol. 15, Issue 1 (2024)As it adds so many advantages to the finished formulations, excipient utilised in pharmaceutical dosage forms is a special and important ingredient that is just as important as the API. Improving API absorption and bioav…
Review ArticlePublished: 5 Dec 2024
MFF Rukshana, Mudiyanselage Imalka Upamali Kumari Tennakoon
pp. 78-85 · DOI: 10.5530/jphi.20251792Vol. 15, Issue 1 (2024)Health entrepreneurship has emerged as a dynamic force shaping the landscape of healthcare delivery, with a particular focus on the pharmaceutical sector. This mini-review aims to investigate and present success stories …
Review ArticlePublished: 5 Dec 2024
Maryam Musleh Althobiti
pp. 86-102 · DOI: 10.5530/jphi.20250002Vol. 15, Issue 1 (2024)Major molecular, physical as well as cellular changes inside their host tissues are enthused by the tumor cells. The evolving TME is an active and multifaceted system. The structure of the TME differs amongst the categor…
Original Article
Original ArticlePublished: 5 Dec 2024
Bariki Rajasekhar, Haranath Chinthaginjala
pp. 103-112 · DOI: 10.5530/jphi.20251733Vol. 15, Issue 1 (2024)INTRODUCTION: The benefit of systemic Donepezil absorption by transdermal patches is that they avoid hepatic first-pass metabolism. They make it possible for drugs to be gradually and carefully released into the bloodstr…
Original ArticlePublished: 5 Dec 2024
Ramakrishna Chintakunta, Lalitha Suresh, Rutushree Amar, Nisarga Mahadevaiah, Lisha Mallesh, S Jeevan Prasad
pp. 113-121 · DOI: 10.5530/jphi.20251753Vol. 15, Issue 1 (2024)Background: Design synthesis of Acetaminophen-chalcone conjugates and finding the in silico studies and characterisation of compounds. Determination of biological activity mainly emphasise on Antibacterial activity. Chal…
Original ArticlePublished: 5 Dec 2024
Repollu Maddileti, Haranath Chinthaginjala
pp. 122-130 · DOI: 10.5530/jphi.20251755Vol. 15, Issue 1 (2024)Background: The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, …
Original ArticlePublished: 5 Dec 2024
Neelima Ganzi, Savitha Rajapur Sanathan, Subhash Chandra Ballekere Jayaram, Easwaran Vigneshwaran
pp. 131-137 · DOI: 10.5530/jphi.20251760Vol. 15, Issue 1 (2024)Background: Medical Intensive Care Unit (MICU) admitted patients have complex drug regimens, serious underlying diseases which increase the risks of Medication-Related Problems (MRP). The study aims to identify, characte…
Original ArticlePublished: 5 Dec 2024
Prashant Nayak, Rompicherla Narayana Charyulu, Alandur Veena Shetty
pp. 138-158 · DOI: 10.5530/jphi.20251766Vol. 15, Issue 1 (2024)Background: By increasing drug stability and water solubility, cycle duration, rate of absorption into target cells or tissues, and reducing enzymatic degradation, Nano Drug Delivery Systems (NDDS) improve the safety and…
Original ArticlePublished: 5 Dec 2024
Ishu Tyagi, Kandasamy Nagarajan, Snigdha Bhardwaj
pp. 159-169 · DOI: 10.5530/jphi.20251789Vol. 15, Issue 1 (2024)Background: Efavirenz is a widely used antiretroviral medication for managing HIV infection, known for its role as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). By targeting and inhibiting the reverse transcr…
Original ArticlePublished: 5 Dec 2024
Sanket Keshav Tambe, Rohit Jaysing Bhor, Shubham Balasaheb Mhaske, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 170-181 · DOI: 10.5530/jphi.20251795Vol. 15, Issue 1 (2024)Background: GPCRs are among the most effective therapeutic target families. They have undergone a transition from ligand screening at random to knowledge-driven drug design. We are seeing first-hand the enormous strides …
Original ArticlePublished: 5 Dec 2024
Mayur Sitaram Gaikwad, Rohit Jaysing Bhor, Mahesh Hari Kolhe, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 182-190 · DOI: 10.5530/jphi.20251804Vol. 15, Issue 1 (2024)Background: It was a heterocyclic hydrocarbon whose molecular structure has some fundamental structural features. In this study, we synthesise eleven different imidazolidine-2,4-dione derivatives that have convulsive pro…
Original ArticlePublished: 5 Dec 2024
Rohit Jaysing Bhor, Harshada Sudhakar Aher, Sanket Keshav Tambe, Mahesh Hari Kolhe, Neha Shyam Bora, Vaijanti Ashok Medge, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Akanksha Kailas Nirmal
pp. 191-198 · DOI: 10.5530/jphi.20251822Vol. 15, Issue 1 (2024)Background: Five-membered heterocycle with one neighbouring nitrogen atoms is present in the indole nucleus. Heterocyclic substances feature two adjacent benzene and pyrrole ring atoms. Indoles are heterocyclic compounds…
Original ArticlePublished: 5 Dec 2024
Taranga Jyoti Baruah, Sanathoi Tongbram, Pratyashi Bora, Shivani Priya, Langlen Meinam, Sanjenbam Kabita
pp. 199-208 · DOI: 10.5530/jphi.20251798Vol. 15, Issue 1 (2024)Background: Xanthine oxidase and tyrosinase are enzymes involved in various functions in the body. Tyrosinase and xanthine oxidase have high activity levels in various diseases like gout hyperpigmentation and neurodegrad…
Original ArticlePublished: 5 Dec 2024
Palanisamy Pethappachetty, Kavya Thirupathi, Phagalavan Moorthy, Mohan Kumar, Manivasakam Prakash, Anandharaj Govindharaj
pp. 209-218 · DOI: 10.5530/jphi.20251622Vol. 15, Issue 1 (2024)Aim/Background: This research explores the pharmaceutical industry’s operations management, focusing on regulatory-based operation management for parenteral preparations. Materials and Methods: The study utilizes a compr…