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International Journal of Pharmaceutical Investigation · Archive

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In this issue

Original Research Article

  1. Original Research ArticlePublished: 1 Jul 2018

    Study on the quality control analysis of antiepileptic drugs using high‑performance liquid chromatography

    Manzoor Ahmad Mir, Najwa Shabir, Umar Mehraj, Younis Mohd Rather, Samina Farhat

    pp. 115-121 · DOI: 10.4103/jphi.JPHI_45_18Vol. 8, Issue 3 (2018)

    Background: Epilepsy is the second most common neurological condition, and antiepileptic drugs(AEDs) are used as a prophylactic measure. Any amount of poor-quality medicine is unacceptable because it increases morbidity …

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  2. Original Research ArticlePublished: 1 Jul 2018

    Anti‑osteoporotic activity of isoflavones from Iris germanica targeting NF‑kappaB

    Afroze Alam, Monika Verma, Kamlesh Kumar Naik, Disha Choudhary, Shailendra Kumar

    pp. 122-129 · DOI: 10.4103/jphi.JPHI_36_18Vol. 8, Issue 3 (2018)

    Background: Most of the available anti‑osteoporotic drugs are costly and possess great threat of severe side effects. Thus, an alternative approach is required to develop new therapeutic drugs. Materials and Methods: An …

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  3. Original Research ArticlePublished: 1 Jul 2018

    Molecular docking studies of ephedrine, eugenol, and their derivatives as arginase inhibitors: Implications in asthma

    Suhasini Donthi, Jayasree Ganugapati, Vijayalakshmi Valluri, Ramesh Macha, Krovvidi S. R. Sivasai

    pp. 130-137 · DOI: 10.4103/jphi.JPHI_25_18Vol. 8, Issue 3 (2018)

    Background: Arginine being a common substrate for arginase and nitric oxide synthase (NOS) an imbalance between enzymes could lead to a shift in airway responses. Reports suggest that increased arginase reduces the subst…

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  4. Original Research ArticlePublished: 1 Jul 2018

    Synthesis, antimicrobial activity, and docking study of some N3 , N6 ‑diphenylpyridazine‑3,6‑diamine derivatives as dihydrofolate reductase inhibitors

    Athar Javed, Sameer Sapra, Afroze Alam

    pp. 138-144 · DOI: 10.4103/jphi.JPHI_37_18Vol. 8, Issue 3 (2018)

    Objective: The present study focussed on the synthesis of pyridazine analogs to explore broad‑spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are stud…

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  5. Original Research ArticlePublished: 1 Jul 2018

    The effectiveness of Valeriana officinalis on sleep disturbance in patients with chronic heart failure

    Fatemeh Aliakbari, Mahmoud Rafieian

    pp. 145-150 · DOI: 10.4103/jphi.JPHI_43_18Vol. 8, Issue 3 (2018)

    Background: Sleep disturbances are common problems in patients with chronic heart failure (CHF) and are a significant contributing factor to fatigue and poor quality of life. The aim of the present study was to evaluate …

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  6. Original Research ArticlePublished: 1 Jul 2018

    Intensive monitoring of adverse drug reactions to antipsychotic medications in the inpatient psychiatry department of a secondary care hospital of UAE

    Haneen Abou R Aburamadan, Sathvik Belagodu Sridhar, Talaat Matar Tadross

    pp. 151-156 · DOI: 10.4103/jphi.JPHI_46_18Vol. 8, Issue 3 (2018)

    Background: Antipsychotics are a class of medications used primarily for the treatment of psychotic disorders. However, these medications are associated with potential adverse drug reactions (ADRs). Aim: To monitor the i…

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