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International Journal of Pharmaceutical Investigation · Archive

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In this issue

Original Research Article

  1. Original Research ArticlePublished: 22 May 2014

    Fast disintegrating crystalline solid dispersions of simvastatin for incorporation into orodispersible tablets

    Ritesh M Pabari, Asha Jamil, John G Kelly, Zebunnissa Ramtoola

    pp. 51-59 · DOI: 10.4103/2230-973X.133029Vol. 4, Issue 2 (2014)

    Aim: Spray dried solid dispersion (SDP) of crystalline simvastatin (SIM) in a fast disintegrating matrix of superdisintegrants was studied as a method to enhance SIM dispersibility, rheology, compactibility and compressi…

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  2. Original Research ArticlePublished: 22 May 2014

    Enhanced transdermal permeability of piroxicam through novel nanoemulgel formulation

    Bhavna Dhawan, Geeta Aggarwal, SL Harikumar

    pp. 65-76 · DOI: 10.4103/2230-973X.133053Vol. 4, Issue 2 (2014)

    Background: Piroxicam is a non-steroidal anti-infl ammatory drug belongs to BCS class II drugs having poor solubility and is associated with a number of undesirable side-effects on the stomach and kidneys in addition to …

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  3. Original Research ArticlePublished: 22 May 2014

    Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 23 factorial design

    Pathuri Lakshmi Sirisha, Govada Kishore Babu, Puttagunta Srinivasa Babu

    pp. 77-87 · DOI: 10.4103/2230-973X.133055Vol. 4, Issue 2 (2014)

    Ambulatory blood pressure monitoring is regarded as the gold standard for hypertensive therapy in non-dipping hypertension patients. A novel compression coated formulation of captopril and hydrochlorothiazide (HCTZ) was …

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  4. Original Research ArticlePublished: 22 May 2014

    Novel sustained release and swellable gastroretentive dosage form for ciprofl oxacin hydrochloride

    Vinay Dhananjay Gaikwad, Vishal Dadasaheb Yadav, Manish Dhananjay Gaikwad

    pp. 88-92 · DOI: 10.4103/2230-973X.133057Vol. 4, Issue 2 (2014)

    Introduction: The present study aims at developing a gastroretentive swellable and fl oating matrix tablet formulation of ciprofl oxacin hydrochloride (HCl) for the effective treatment of infections caused by susceptible…

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  5. Original Research ArticlePublished: 22 May 2014

    Design and optimization of bilayered tablet of Hydrochlorothiazide using the Quality-by-Design approach

    Yatin N Dholariya, Yogesh B Bansod, Rahul M Vora, Sandeep S Mittal, Ajinath Eknath Shirsat, Chandrashekhar L Bhingare

    pp. 93-101 · DOI: 10.4103/2230-973X.133058Vol. 4, Issue 2 (2014)

    Aim: The aim of the present study is to develop an optimize bilayered tablet using Hydrochlorothiazide (HCTZ) as a model drug candidate using quality by design (QbD) approach.Introduction and Method: The bilayered tablet…

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  6. Original Research ArticlePublished: 22 May 2014

    Development of co-processed excipients in the design and evaluation of atorvastatin calcium tablets by direct compression method

    Ravi Teja Pusapati, MVR Kalyan Kumar, Siva Satyanandam Rapeti, TEGK Murthy

    pp. 102-106 · DOI: 10.4103/2230-973X.133059Vol. 4, Issue 2 (2014)

    Introduction: Co-processed excipients were prepared to improve the process ability and effi cacy of commonly used excipients and to impart multi-functional qualities to the excipients and hence that the tablets with the …

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