International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 27Review Article
Review ArticlePublished: 16 Dec 2022
Abhishek Srivastava, Mohammad Ahmad Khan, Simrata Bedi, Uma Bhandari
pp. 1-6 · DOI: 10.5530/223097131574Vol. 13, Issue 1 (2022)Ticagrelor is a BCS class IV drug that inhibits platelet action by reversibly binding to the P2Y12 receptor. One of the major challenges faced by the class IV (low solubility, low permeability) drug is the lower dissolut…
Review ArticlePublished: 16 Dec 2022
Indu Raghunath, Marina Koland, Anoop Narayanan Vadakkepushpakath, Lalit Kumar, Sarathchandran Chandra Shekhar Shenoy
pp. 7-13 · DOI: 10.5530/223097131736Vol. 13, Issue 1 (2022)The oral delivery of protein and peptide drugs faces immense challenges due to the harsh gastrointestinal (GI) environment, large molecular size, and low stability. Even though different approaches are employed to delive…
Review ArticlePublished: 16 Dec 2022
Sandeep Grover, B.M. Gupta, K.K. Mueen Ahmed, Yogindra Singh
pp. 14-21 · DOI: 10.5530/223097130001Vol. 13, Issue 1 (2022)Aim: This study evaluates the research output on Clozapine included in Scopus database during 1970-2021. Materials and Methods: The quantitative and qualitative analysis of publications on “Clozapine” covered in Scopus d…
Original Article
Original ArticlePublished: 16 Dec 2022
Dara Suneeta, YRKV Tirupathi Rao
pp. 22-27 · DOI: 10.5530/223097131566Vol. 13, Issue 1 (2022)Background: Ixora pavetta and Tecoma capensis are two less explored and neglected plants species in medicinal prospective. The flowers bark and root of I. pavetta used as a remedy for cough, anaemia, women urinary proble…
Original ArticlePublished: 16 Dec 2022
Sarika Nikam, Shilpa Chaudhari
pp. 28-36 · DOI: 10.5530/223097131651Vol. 13, Issue 1 (2022)Objectives: Traditional method of optimization is lengthy and time consuming while response surface methodology evaluates the effects of multiple factors and their interactions on one or more response variables with fewe…
Original ArticlePublished: 16 Dec 2022
Machavarapu Neelima, Yekkala Prathyusha, Mamindla Archana, Thirunagiri Praveen kumar
pp. 37-42 · DOI: 10.5530/223097131669Vol. 13, Issue 1 (2022)Introduction: Respiratory tract infection (RTI) is defined as any upper or lower respiratory tract infectious disease. Globally, respiratory infections are the leading cause of infant and child mortality and a substantia…
Original ArticlePublished: 16 Dec 2022
Mandar Ambike, Nabilah Kazi, Arun Prasad, Dnyandeo Chopade, Suresh Kondaveeti
pp. 43-47 · DOI: 10.5530/223097131714Vol. 13, Issue 1 (2022)Background: A well-established finding is that thyroid disease is seen more commonly in individuals suffering from Down’s Syndrome than in people without the condition. Patients are at risk from childhood to adulthood. T…
Original ArticlePublished: 16 Dec 2022
Paviterjeet Singh, Shweta Singla, Rajiv Mahajan, Rakendra Singh, Manish Kumar Gupta
pp. 48-52 · DOI: 10.5530/223097131715Vol. 13, Issue 1 (2022)Background: Adverse Drug Reactions (ADRs) are amongst the commonly occurring event in the intensive care unit where patients are mostly on the polypharmacy. They affect the quality of life of patients and increase the bu…
Original ArticlePublished: 16 Dec 2022
Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model
Supriya Bhowmick, Deblina Giri, Meghamala Mandal, Shrabanti Pyne, Pinku Pal, Sanjay Das, Dilip Kumar Nandi, Koushik Das
pp. 53-61 · DOI: 10.5530/223097131728Vol. 13, Issue 1 (2022)Background: Chronic kidney disease is now a global burden with an increased grade of morbidity and mortality due to the unavailability of particular medicines except for high-cost treatments like dialysis or kidney trans…
Original ArticlePublished: 16 Dec 2022
Sunil Harer, Manish Bhatia, Priyanka Sonar
pp. 62-73 · DOI: 10.5530/223097131749Vol. 13, Issue 1 (2022)Objectives: Substituted quinazolin-4(3H)-ones at position-3 with phenyl ring, heterocycles and aliphatic moieties, were reported to impart antimicrobial activities. In light of this, we have attempted to prepare a novel …
Original ArticlePublished: 16 Dec 2022
Kinjal Patel, Keyur Patel, Maitreyi Zaveri
pp. 74-81 · DOI: 10.5530/223097131792Vol. 13, Issue 1 (2022)Background: More than 85% of young people around the world suffer from acne vulgaris, which is the most prevalent chronic inflammatory skin illness. The study’s objective was to develop a herbal patch formulation contain…
Original ArticlePublished: 16 Dec 2022
Deepak K. Dwivedi, Ram Kishore Agrawal
pp. 82-86 · DOI: 10.5530/223097131793Vol. 13, Issue 1 (2022)Background: Breast cancer is the highest mortality-causing disease among cancers in women and it can be cured by early diagnosis as well as treatment. Epidermal growth factor receptor-2 (HER2) is the prime factor that he…
Original ArticlePublished: 16 Dec 2022
Pritish Kumar Panda, Sanjay K. Jain
pp. 87-93 · DOI: 10.5530/223097131799Vol. 13, Issue 1 (2022)Objectives: Doxorubicin-bearing polymeric (PLGA) nanoparticles (PNPs) were prepared for the treatment of prostate cancer. Materials and Methods: These PNPs were prepared using the solvent evaporation method and character…
Original ArticlePublished: 16 Dec 2022
Shivani Saraf, Priyanka Pahade, Devashish Bose, Sanjay K. Jain
pp. 94-99 · DOI: 10.5530/223097131802Vol. 13, Issue 1 (2022)Objectives: This study aimed to develop a micellar liquid chromatography-based simultaneous estimation method for the analysis of topotecan and capsaicin. Materials and Methods: The Liquid chromatographic system consiste…
Original ArticlePublished: 16 Dec 2022
Laxmikant Gautam, Suresh P. Vyas
pp. 100-105 · DOI: 10.5530/223097131810Vol. 13, Issue 1 (2022)Recent studies have focused heavily on tumor-oriented nanocarriers mediated by cell- penetrating peptides (CPPs). However, the loss of CPPs in normal tissues and enzymatic degradation in circulation frequently prevented …
Original ArticlePublished: 16 Dec 2022
Pradnya Zambare, Avinash Survase, Shivangi Kanase
pp. 106-112 · DOI: 10.5530/223097131692Vol. 13, Issue 1 (2022)Objectives: We reported a non-toxic, low-cost and environmentally friendly green synthesis technique for the manufacture of copper nanoparticles (Cu NPs) utilizing Ocimum sanctum (O. sanctum) leaf extract to prevent hosp…
Original ArticlePublished: 16 Dec 2022
Ibrahim Baje Syed, Madhavi Nannapaneni
pp. 113-121 · DOI: 10.5530/223097131696Vol. 13, Issue 1 (2022)Background: Axitinib was used to treat carcinoma of renal cells and Upadacitinib was used to treat rheumatoid arthritis and Zanubrutinib used as an anti cancer medication for mantle cell lymphoma. In the current applicat…
Original ArticlePublished: 16 Dec 2022
Mohammad Rashid Iqbal, Satish Kumar Sharma
pp. 122-128 · DOI: 10.5530/223097131721Vol. 13, Issue 1 (2022)Aim: The present study was to investigate the effects of WSE improve cognitive, behavioral and mood disorders in animal models of bipolar disorder. Materials:Animals were divided into six groups each group contain 6 wist…
Original ArticlePublished: 16 Dec 2022
Bashir A Sheikh, Basharat A Bhat, Masood A Rizvi, Zahoor Ahmad, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor A Mir
pp. 129-138 · DOI: 10.5530/223097131750Vol. 13, Issue 1 (2022)Background: DprE1, which is a flavoenzyme, is very important for cell wall biosynthesis in Mycobacterium tuberculosis (Mtb) and for the pathogenesis, virulence, lethality, and stress resistance of the host. Drug-resistan…
Original ArticlePublished: 16 Dec 2022
Vikash Gupta, Mohan Lal Kori
pp. 139-148 · DOI: 10.5530/223097131485Vol. 13, Issue 1 (2022)Background: Diabetes becomes a chronic disease when glucose constantly remains high and uncontrolled. As time goes off, it may gradually develop acute or chronic associated complications. Diabetic neuropathy is one of th…