International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 34Review Article
Review ArticlePublished: 12 Feb 2025
Muhammad Abid Mustafa, Aqsa Malik, Eman Javed, Aliza Amjad, Sana Iqbal, Eman Mustafa, Namra Rasheed, Aqsa Shafiq, Muhammad Fahad, Maryam Mughal, Gohar Jaan, Nageen Ramzan
pp. 313-324 · DOI: 10.5530/ijpi.20250024Vol. 15, Issue 2 (2025)This review explores the role of additive manufacturing, particularly 3D printing, as an innovative approach in targeted drug delivery. It effectively addresses the limitations of traditional methods, such as high costs,…
Review ArticlePublished: 12 Feb 2025
K N Pooja, D R Bharathi, Syed Sagheer Ahmed, B M Jayanth, K Chandan
pp. 325-333 · DOI: 10.5530/ijpi.20250047Vol. 15, Issue 2 (2025)Precision medicine in diabetes management is a groundbreaking approach that tailors treatment strategies to individual patients, moving beyond the one-size-fits-all model. It leverages genetic, molecular and lifestyle da…
Review ArticlePublished: 12 Feb 2025
Lakshmi Prasanthi Nori, Maddala Lohitha, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Sudarshan Rao Nagineni, Venkateswara Raju Kalidindi
pp. 334-360 · DOI: 10.5530/ijpi.20250100Vol. 15, Issue 2 (2025)Artificial Intelligence (AI) is ushering in a transformative era for personalized medicine by customizing therapeutic interventions based on individual patient profiles, including genetic information and environmental in…
Review ArticlePublished: 12 Feb 2025
Kamalesh Dilip Mali, Durgesh Tulshiram Shinde, Kalpesh Ravindra Patil
pp. 344-360 · DOI: 10.5530/ijpi.20250146Vol. 15, Issue 2 (2025)Solubility enhancers are one way to get around the difficulties with medication absorption and dissolution in oral drug delivery, since many novel active pharmaceutical components are not well soluble in water. The effic…
Review ArticlePublished: 12 Feb 2025
Saniya Makkad, Mujibullah Sheikh, Sanskruti Shende, Pranita Jirvankar
pp. 361-376 · DOI: 10.5530/ijpi.20251676Vol. 15, Issue 2 (2025)Pharmaceutical excipients are integral to therapeutic formulations; their importance has grown from inert and economical materials to components that make up 80-90% of the finished product. This review examines the excip…
Review ArticlePublished: 12 Feb 2025
Sanjiv Kumar Gupta, Neelesh Chaubey
pp. 377-387 · DOI: 10.5530/ijpi.20251793Vol. 15, Issue 2 (2025)Nanoemulsion-based nanogels have emerged as a promising approach for treating fungal infections due to their unique properties. Nanoemulsions are fine oil-in-water or water-in-oil dispersions stabilized by surfactants, c…
Original Article
Original ArticlePublished: 12 Feb 2025
Bysani Suresh Babu, Nalanda Revu Baby, Sumanta Mondal
pp. 388-396 · DOI: 10.5530/ijpi.20250004Vol. 15, Issue 2 (2025)Objectives: This study describes developing and validating a novel method using LC-MS/ MS to measure the concentration of Momelotinib in rat plasma. Materials and Methods: The pharmacokinetic applicability of the process…
Original ArticlePublished: 12 Feb 2025
Bipin Shaji, Juno Jerold Joel, Raghava Sharma, Shraddha Shetty
pp. 397-406 · DOI: 10.5530/ijpi.20250019Vol. 15, Issue 2 (2025)Background: Hypothyroidism is characterized by an underactive thyroid gland. As thyroid hormones are essential for regulating metabolism, disruptions in secretions can cause metabolic syndrome. This study is to assess th…
Original ArticlePublished: 12 Feb 2025
Shamita Shyam Sail, Akshata Gore, Arfa Anwar Sayed, Mohd Ramish Khan, AHM Viswanatha Swamy, BM Dayana, Sanatkumar Bharamu Nyamagoud
pp. 407-416 · DOI: 10.5530/ijpi.20250035Vol. 15, Issue 2 (2025)Background: Materiovigilance is important for checking the safety and effectiveness of medical devices. There isn't much research on how pharmacy students understand and perceive about materiovigilance. To understand thi…
Original ArticlePublished: 12 Feb 2025
KM Sowmya, RT Narendhirakannan
pp. 417-433 · DOI: 10.5530/ijpi.20250039Vol. 15, Issue 2 (2025)Background: Nanoparticles, particularly those from natural sources like E. cardamomum, have garnered significant interest due to their unique physicochemical characteristics and potential applications in medicine. Materi…
Original ArticlePublished: 12 Feb 2025
Prasad Dilip Kadam, Ganpat Ram Nagargoje, Abhay Shivajirao Bondge, Kalimoddin Inayatsab Momin, Sharad Pandit Panchgalle, Vijaykumar Shivdas More
pp. 434-442 · DOI: 10.5530/ijpi.20250040Vol. 15, Issue 2 (2025)Background: The study focuses on the synthesis of novel 4-Hydrazinyl-7H-Pyrrolo[2,3-d] Pyrimidine (HPP) derivatives using microwave-assisted synthesis starting from substituted benzaldehydes (a-j) and HPP in the presence…
Original ArticlePublished: 12 Feb 2025
Mithun Bandivadekar, Ashwini Madgulkar, Syed Mubashir Rashid, Ranjitkumar Padakanti, Vedanti Godbole
pp. 443-453 · DOI: 10.5530/ijpi.20250042Vol. 15, Issue 2 (2025)Background: Anti-retroviral drugs are challenging formulation scientists due to their poor solubility problem. This criticality increases when the drug has to be delivered by a vaginal route where the availability of flu…
Original ArticlePublished: 12 Feb 2025
Aneesha Addanki, Rama Rao Nadendla, Vijaya Kishore Kanakaraju
pp. 454-461 · DOI: 10.5530/ijpi.20250068Vol. 15, Issue 2 (2025)Background: Alzheimer's disease has become a serious health problem in recent years. Certain acetylcholinesterase inhibitors have been shown to have anti-Alzheimer's properties. In the current work, a number of oxazepine…
Original ArticlePublished: 12 Feb 2025
Revathi Sundaramoorthi, Anitha Pavadai, Jenifer Sathappan, Senthil Rajan Sivakumar
pp. 462-470 · DOI: 10.5530/ijpi.20250074Vol. 15, Issue 2 (2025)Background: The solubility of medications significantly affects their absorption and therapeutic effectiveness. Drugs with poor solubility often faces challenges in formulation development leading to low bioavailability …
Original ArticlePublished: 12 Feb 2025
Suresh Yerramsetty, Lavanya Ayyagari, Venkata Krishna Kanth Makani, Jolly Janette Mendonza, Suchitra Maheswari Ajjarapu, Ahmed Kamal, Smita C. Pawar, Manika Pal Bhadra
pp. 471-481 · DOI: 10.5530/ijpi.20250079Vol. 15, Issue 2 (2025)Aim: To investigate the neuroprotective and anti-apoptotic effects of an anthranilamide pyrazolo[1,5-a] pyrimidine derivative(C2) in a Parkinson’s Disease (PD) model using rotenone-induced SH-SY5Y cells. Background: Alth…
Original ArticlePublished: 12 Feb 2025
Dipti Gohil, Ujjaval Patel, Priyank Patel, Nirmal Shah, Sunil Kardani
pp. 482-489 · DOI: 10.5530/ijpi.20250086Vol. 15, Issue 2 (2025)Background: Rheumatoid arthritis causes chronic joint pain and inflammation, significantly impacting quality of life. Current treatments are limited, with oral Leflunomide commonly used. However, prolonged oral administr…
Original ArticlePublished: 12 Feb 2025
Jawahar Natarajan, Pavalan Krishnan, Sebatini Sinsi Arokianathan, Sharuni Sivakumar, Parish Vendar Saravanan, Roshan Prasad Rao
pp. 490-497 · DOI: 10.5530/ijpi.20250087Vol. 15, Issue 2 (2025)Objectives: Sunscreen cosmeceuticals play a crucial role in protecting the skin from dangerous ultraviolet radiation, which is linked to various dermatological diseases and skin cancers. Avobenzone is extensively used or…
Original ArticlePublished: 12 Feb 2025
Balakrishna Talamanchi, Lakshman Kumar Dogiparthi, Bala Sree Sanjeevi Pusala, Roshni Patan, Vamsi Abhiram Yadlapalli, Vinay Simhadri, Shahid Hussain Shaik, Yasaswini Vakkalagadda
pp. 498-507 · DOI: 10.5530/ijpi.20250095Vol. 15, Issue 2 (2025)Introduction: The goal of this study was to develop and evaluate Bosentan transdermal patches for the treatment of Pulmonary Arterial Hypertension (PAH), which is defined as an abnormally high blood pressure in the arter…
Original ArticlePublished: 12 Feb 2025
Rhea Surana Lalit, K Karthika, Kavitha Ramasamy
pp. 508-515 · DOI: 10.5530/ijpi.20250103Vol. 15, Issue 2 (2025)Objectives: Zolpidem, a novel non-benzodiazepine sedative, has shown antioxidant, muscle relaxant, anti-convulsant and anti-anxiety properties. The Objective of our study is to evaluate it’s in vitro anti-inflammatory ac…
Original ArticlePublished: 12 Feb 2025
Sunil Rayudu, Medikonda Manoranjani, D Anitha
pp. 516-523 · DOI: 10.5530/ijpi.20250109Vol. 15, Issue 2 (2025)Background: An accurate, rapid, inexpensive, and straightforward, reliable simultaneous assay technique was developed and demonstrated to evaluate Levodopa and Benserazide using RP-HPLC. Materials and Methods: The sugges…