International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 41Review Article
Review ArticlePublished: 21 Jul 2025
Mohomed Faizal Umair Ahamed, Gothai Sivapragasam, Nanthini Sridewi Appan
pp. 1065-1072 · DOI: 10.5530/ijpi.20250125Vol. 15, Issue 4 (2025)This review offers an overview of the crucial role microglia play in neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. It also delves into the therapeutic potential of natural produc…
Review ArticlePublished: 21 Jul 2025
Abdulhadi M Abdulwahed
pp. 1073-1085 · DOI: 10.5530/ijpi.20250384Vol. 15, Issue 4 (2025)This review aims to discuss the progress made in targeted drug delivery of small molecules in breast cancer, as well as the methods that can be used to increase the accuracy of the treatment and reduce the overall toxici…
Review ArticlePublished: 21 Jul 2025
Gopinath Govindarajan, Ranganadhareddy Aluru
pp. 1086-1095 · DOI: 10.5530/ijpi.20250277Vol. 15, Issue 4 (2025)In biopharmaceutical manufacturing chromatography technique has been the backbone of purification process. As bioprocessing has advanced, a growing trend has emerged toward gaining a thorough understanding of the fundame…
Review ArticlePublished: 21 Jul 2025
Rajendran Akash, Sathiyamoorthy Rajesh, Bhuvaragavan Devishree, Karthikeyan Aravind, Selvaraj Deepa, Kesavan Sathesh Kumar
pp. 1096-1107 · DOI: 10.5530/ijpi.20250319Vol. 15, Issue 4 (2025)This review article provides a comprehensive examination of collagen-loaded dental applications, focusing on collagen dental plugs used for socket preservation and tissue regeneration following tooth extraction. It explo…
Review ArticlePublished: 21 Jul 2025
Ajay Charan, Lita Susan Thomas, Vaishali Bambal, Vanaja Kenchappa, Anju Jose
pp. 1108-1121 · DOI: 10.5530/ijpi.20250508Vol. 15, Issue 4 (2025)Ventilator-Associated Pneumonia (VAP) is a prevalent and serious hospital-acquired infection occurring in critically ill patients who have been mechanically ventilated for over 48 hr. It is primarily caused by Gram-negat…
Review ArticlePublished: 21 Jul 2025
Mahavir M. Sharma, Harshkumar Brahmbhatt, Priyanka Shah, Ujjval P. Vaghela
pp. 1122-1129 · DOI: 10.5530/ijpi.20250488Vol. 15, Issue 4 (2025)This review delineates the primary objectives of Quality by Design (QbD) and provides an in-depth exposition of its foundational concepts. The core components of QbD include: (1) the establishment of a comprehensive cont…
Review ArticlePublished: 21 Jul 2025
Venkateswara Raju Kalidindi, Gutturu Dheeraj Balaji, Uda Mahalakshmi, Sirilla Dinesh Babu, Badugu Priyanka, Tekumudi Vasantha Naga Lakshmi, Lakshmi Prasanthi Nori
pp. 1130-1143 · DOI: 10.5530/ijpi.20250005Vol. 15, Issue 4 (2025)Decentralized Clinical Trials (DCT) utilize digital health technologies, remote monitoring, and telehealth, eliminating the need for traditional in-person visits to clinical sites. This model provides significant benefit…
Review ArticlePublished: 21 Jul 2025
Lakshmi Prasanthi Nori, Ketha Bhavani, Yamini Satya Sri, Gangomolu Pujitha, Kiran Manda, Sudarshan Rao Nagineni, Kalidindi Venkateswara Raju
pp. 1144-1152 · DOI: 10.5530/ijpi.20250006Vol. 15, Issue 4 (2025)Materiovigilance refers to the system of safety monitoring and performance of medical devices after being placed on the market and involves collecting, analyzing, and responding to reports of malfunctions, adverse events…
Review ArticlePublished: 21 Jul 2025
Jiafeng Li, Tiefeng Jin, Meihua Zhang
pp. 1153-1159 · DOI: 10.5530/ijpi.20250329Vol. 15, Issue 4 (2025)The "Four New" initiatives have emerged as a pivotal framework for advancing higher education in China. Among these, the promotion of New Medical Sciences not only meets the evolving demands of the contemporary era but a…
Review ArticlePublished: 21 Jul 2025
Sagar Mysore Shivakumar, Rashmi Nelligare Gopalakrishna
pp. 1160-1167 · DOI: 10.5530/ijpi.20250255Vol. 15, Issue 4 (2025)Endophytic fungi have engrossed the most attention owing to their prospect of being a source of many bioactive compounds. These fungi are regarded as effective producers of valuable metabolites, such as antibacterial, an…
Original Article
Original ArticlePublished: 21 Jul 2025
Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Abida Haripriya Rammohan, Dharshini Sagadevan, Udhayakumar Thangavelu
pp. 1168-1174 · DOI: 10.5530/ijpi.20250175Vol. 15, Issue 4 (2025)Objectives: This study centers on the development and assessment of a facial serum fortified with the innate antioxidant’s resveratrol and quercetin, to address skin aging and acne. Materials and Methods: The serum was c…
Original ArticlePublished: 21 Jul 2025
Harshitha Nagaraj, Kusu Susan Cyriac, Deepak Kumar Jha
pp. 1175-1183 · DOI: 10.5530/ijpi.20250149Vol. 15, Issue 4 (2025)Background: Inflammation is the body's innate defence mechanism that is initiated in reaction to injury or on exposure to detrimental agents. Plumeria alba Linn, a small laticiferous tree rich in phytochemicals and antio…
Original ArticlePublished: 21 Jul 2025
Amaresh Chandra Sahoo, Sujit Dash, Prabhat Kumar Sahoo, Minaketan Sahoo
pp. 1184-1194 · DOI: 10.5530/ijpi.20250206Vol. 15, Issue 4 (2025)Background: Emulgel is a combination of gel and emulsion. Drugs are first incorporated into an emulsion and then the conventional emulsion is transferred into an emulgel by using a gelling agent. Objectives: To formulate…
Original ArticlePublished: 21 Jul 2025
Ang Wan Yi, Mukhri Hamdan, Giribabu Nelli
pp. 1195-1205 · DOI: 10.5530/ijpi.20250416Vol. 15, Issue 4 (2025)Background: Male infertility is associated with vitamin D deficiency, and much evidence suggests ways to correct this deficiency to restore fertility. Vitamin D supplementation in men significantly improved fertility and…
Original ArticlePublished: 21 Jul 2025
Gobu, Emmanuel, Daniel Sundar Singh, Prakashraj Elumalai, Roshan Nawaz Ayas, Solai Ganesh Subburaj
pp. 1206-1213 · DOI: 10.5530/ijpi.20250299Vol. 15, Issue 4 (2025)Background: Cardiovascular diseases are increasingly becoming a major cause of morbidity and mortality around the world. About half of the deaths due to non-communicable diseases are attributed to some form of cardiovasc…
Original ArticlePublished: 21 Jul 2025
Rajendran, Sudesh Raj, Tejas, Jayakumar, Sneha, Reethi
pp. 1214-1226 · DOI: 10.5530/ijpi.20250211Vol. 15, Issue 4 (2025)Background: Ashwagandha (Withania somnifera), traditionally valued for enhancing stress resilience, is known for its neuroprotective and antioxidant effects. This study explores the Orgaheal™ Ashwagandha with Valerian Ro…
Original ArticlePublished: 21 Jul 2025
Monish Mukul Das, Sayan Chakraborty, Avijit Mondal, Tapas Guha
pp. 1227-1234 · DOI: 10.5530/ijpi.20250261Vol. 15, Issue 4 (2025)Background: Staphylococcus aureus is a gram-positive pathogen which contributes community-associated and nosocomial serious diseases and it has become resistant to various antimicrobials. Owing to rapid advent and contin…
Original ArticlePublished: 21 Jul 2025
Rashed Mohammed Alghamdi
pp. 1235-1248 · DOI: 10.5530/ijpi.20250268Vol. 15, Issue 4 (2025)Background: Non-Small Cell Lung Cancer (NSCLC) epitomizes 85% of lung cancer cases with poor survival rates. Understanding molecular mechanisms through gene expression analysis is important for developing real treatments…
Original ArticlePublished: 21 Jul 2025
Belum Jyoshna, Vadlavari Pavan Chandu, Valmiki Uday Sai, Gaddam Vamsidhar Reddy, Bandi Sai Supraja, Caleerappa Ravi Shankar, Akkiraju Sudheer
pp. 1249-1253 · DOI: 10.5530/ijpi.20250300Vol. 15, Issue 4 (2025)Background: According to WHO Drug Utilization research, it is defined as "the marketing, distribution, prescription, and use of drugs in a society, with special emphasis on the resulting medical, social, and economic con…
Original ArticlePublished: 21 Jul 2025
Sandeep Subhash Sagare, Srinivas Prasad Buduru, Kavita Sutagatti, Zeba Mulla
pp. 1254-1260 · DOI: 10.5530/ijpi.20250306Vol. 15, Issue 4 (2025)Background/Purpose: Anemia poses a significant public health challenge, particularly in developing nations. Indian government has initiated several programs aimed at reducing the prevalence of anemia, such as providing i…