International Journal of Pharmaceutical Investigation · Archive
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In this issue
Editorial
EditorialPublished: 20 Aug 2015
Ningning Yang
pp. 179-181 · DOI: 10.4103/2230-973X.167646Vol. 5, Issue 4 (2015)MicroRNAs (miRNAs) are small endogenous noncoding RNAs that direct posttranscriptional regulation of gene expression. Mature miRNAs function as components of RNA-induced silencing complex and interact directly with the 3…
Review Article
Review ArticlePublished: 20 Aug 2015
Saba Khan, Sanjula Baboota, Javed Ali, Sana Khan, Ramandeep Singh Narang, Jasjeet Kaur Narang
pp. 182-191 · DOI: 10.4103/2230-973X.167661Vol. 5, Issue 4 (2015)Nowadays exploration of novel lipid-based formulations is akin to a magnet for researchers worldwide for improving the in vivo performance of highly lipophilic drugs. Over the last few years, new compositions of lipids h…
Review ArticlePublished: 20 Aug 2015
Ansh Dev Ravi, D Sadhna, D Nagpaal, L Chawla
pp. 192-199 · DOI: 10.4103/2230-973X.167662Vol. 5, Issue 4 (2015)Needle free injection technology (NFIT)is an extremely broad concept which include a wide range of drug delivery systems that drive drugs through the skin using any of the forces as Lorentz, Shock waves, pressure by gas …
Original Research Article
Original Research ArticlePublished: 20 Aug 2015
Kannissery Pramod, Salim Shanavas, Shahid H. Ansari, Javed Ali
pp. 200-204 · DOI: 10.4103/2230-973X.167669Vol. 5, Issue 4 (2015)Introduction: Development of novel biomaterials for drug delivery which forms a part of the so called novel drug delivery systems has always been exhilarating. Mechanical evaluation of polymer based topical gels, which w…
Original Research ArticlePublished: 20 Aug 2015
Ramprasad Chintalapudi, T. E. G. K. Murthy, K. Rajya Lakshmi, G. Ganesh Manohar
pp. 205-213 · DOI: 10.4103/2230-973X.167676Vol. 5, Issue 4 (2015)Background: The aim of the present study was to formulate and optimize the self-emulsifying drug delivery systems (SEDDS) of nevirapine (NVP) by use of 22 factorial designs to enhance the oral absorption of NVP by improv…
Original Research ArticlePublished: 20 Aug 2015
Prabhakara Prabhu, Akhilesh Dubey, Vinod Parth, Vivek Ghate
pp. 214-225 · DOI: 10.4103/2230-973X.167684Vol. 5, Issue 4 (2015)Background: Hydrogel is a cross-linked network of polymers. Water penetrates these network causing swelling and giving the hydrogel a soft and rubbery consistency and there by maintaining the integrity of the membrane. D…
Original Research ArticlePublished: 20 Aug 2015
Jyotsana R Madan, Bhushan R Adokar, Kamal Dua
pp. 226-233 · DOI: 10.4103/2230-973X.167686Vol. 5, Issue 4 (2015)Aim and Background: Pregabalin (PRG), an analog of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and comp…
Original Research ArticlePublished: 20 Aug 2015
Ankita Gupta, Gaurav Tiwari, Ruchi Tiwari, Rishabh Srivastava
pp. 234-246 · DOI: 10.4103/2230-973X.167688Vol. 5, Issue 4 (2015)Introduction: The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Mater…
Original Research ArticlePublished: 20 Aug 2015
Mihir K. Raval, Jaydeep M. Patel, Rajesh K. Parikh, Navin R. Sheth
pp. 247-258 · DOI: 10.4103/2230-973X.167689Vol. 5, Issue 4 (2015)Purpose: The aim of the present work was to improve rate of dissolution and processing parameters of BCS class II drug, chlorzoxazone using cogrinding technique in the presence of different excipients as a carrier. Mater…
Original Research ArticlePublished: 20 Aug 2015
Arezoo Amanatfard, Payam Khazaeli, Abbas Pardakhty, Moslem Lari Najafi, Amin Mohammadi
pp. 259-265 · DOI: 10.4103/2230-973X.167691Vol. 5, Issue 4 (2015)Introduction: The insect repellent compounds are used to protect humans, animals and plants against insect bites. Aromatic amides have insect repellent effects. N,N-diethyl-meta-toluamide (DEET) (C12H17NO) is one of the …
Original Research ArticlePublished: 20 Aug 2015
Nidhi Garg, Parijat Pandey, Deepak Kaushik, Harish Dureja
pp. 266-274 · DOI: 10.4103/2230-973X.167692Vol. 5, Issue 4 (2015)Introduction: The objective of the present investigation was to develop a novel multifunctional directly compressible co-processed excipient consisting of dibasic calcium phosphate anhydrous, polyethylene glycol 4000 (PE…
Original Research ArticlePublished: 20 Aug 2015
Avinash Bhaskar Gangurde, Ajay Kumar Sav, Sharadchandra Dagadu Javeer, Kailas K Moravkar, Jaywant N Pawar, Purnima D Amin
pp. 275-283 · DOI: 10.4103/2230-973X.167696Vol. 5, Issue 4 (2015)Introduction: Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as developmen…