International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 47Review Article
Review ArticlePublished: 16 Oct 2026
Gogula Priya, Chinthaginjala Haranath, Donnepati Pradeep Sai, Konda Sai Megha, Sugur Samhitha, Vallapureddy Vasanthi, Kopparapu Maddi Venkata Ramu, Talapula Santhosh Kumar, Lingadahalli Bilwa Malini, Kotra Mounika
pp. 1-8 · DOI: 10.5530/ijpi.20270203Vol. 17, Issue 1 (2027)Cannabis sativa is the primary source of phytocannabinoids, which are meroterpenoids with a resorcinol core that are also present in other plant species such as Helichrysum and Echinacea. There are over more than 100 phy…
Review ArticlePublished: 16 Oct 2026
Kaniga Pandi, Binoy Varghese Cheriyan, Kumaraguru, Bhavya Ekambaram, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Jai Anand Jagadeesan, Dinesh Kumar Eshwaravelu, Pradhosh Sakthivel, Rajeshkumar Thirupathi
pp. 9-20 · DOI: 10.5530/ijpi.20270069Vol. 17, Issue 1 (2027)Rabies remains a fatal zoonotic disease and a significant public health concern, particularly in underdeveloped countries. Although effective vaccines exist, early diagnosis and timely intervention are limited due to the…
Review ArticlePublished: 16 Oct 2026
Brahmaiah Bonthagarala, Sirisha Arige, Gadamsetti Naga Sai AnupamaSri, Mathi Queeny Hadassa, Chekuri Jahnavi, Choppala Jhaneesha, Kandukuri Sri Venkata Lakshmi, Kasilinka Kavya Sri, Rama Rao Vadapalli
pp. 21-29 · DOI: 10.5530/ijpi.20270233Vol. 17, Issue 1 (2027)Breast cancer remains a ubiquitous malignancy affecting women across the world, especially in aggressive subtypes like triple-negative breast cancer and HER2-positive tumors. Although conventional modalities like chemoth…
Review ArticlePublished: 16 Oct 2026
Kaniga Pandi, Binoy Varghese Cheriyan, Sudharshini Srinivasan, Praveen Kumar Ramesh, Bhuvanesh Raj, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Jubilee Ramsamy, Yokesh Shanmugam, Maha Swetha Kannuchamy, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu
pp. 30-50 · DOI: 10.5530/ijpi.20270285Vol. 17, Issue 1 (2027)Bone remodeling is a tightly regulated physiological process governed by the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Emerging evidence highlights the immune system as a critical…
Review ArticlePublished: 16 Oct 2026
Madhavi Nimmathota, Billa Sravani, Medapatla Hari Priya, Uma Maheshwara Rao Vattikuti
pp. 51-62 · DOI: 10.5530/ijpi.20270001Vol. 17, Issue 1 (2027)Non-invasive nasal drug delivery systems have emerged as a promising route for drug administration. It facilitates rapid therapeutic effect, bypass first pass metabolism, increase patient compliance and provides nose-to-…
Review ArticlePublished: 16 Oct 2026
Chitrali Talele, Dipali Talele, Yogita Shinde, Archana Shaha, Niyati Shah, Chintan Aundhia
pp. 63-76 · DOI: 10.5530/ijpi.20270046Vol. 17, Issue 1 (2027)Mucosal drug delivery has emerged as a promising strategy for both local and systemic therapeutic administration due to its non-invasive nature and extensive absorptive surface area. However, the protective mucus barrier…
Review ArticlePublished: 16 Oct 2026
Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Subathra Sundar, Maheswari Murugan, Tarunika Balaji, Aswini Sreenivasan
pp. 77-85 · DOI: 10.5530/ijpi.20270070Vol. 17, Issue 1 (2027)Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine illnesses affecting women of reproductive age. It is distinguished by hyperandrogenism, ovulatory failure, and polycystic ovarian morphology. The syndr…
Review ArticlePublished: 16 Oct 2026
Kamalesh Dilip Mali, Sachin Yadav, Arya Nilesh Dubey, Gaurav Bharat Deore
pp. 86-103 · DOI: 10.5530/ijpi.20270097Vol. 17, Issue 1 (2027)Poor aqueous solubility remains a critical challenge in pharmaceutical development, leading to limited drug absorption, high variability in systemic exposure, and reduced therapeutic efficiency. Conventional approaches s…
Review ArticlePublished: 16 Oct 2026
Gorinkala Bhargavi Sudeeshna, M Mohan Varma, K.T. Sunil Kumar, Arumalla Sai Joshitha, Sujitha Pithani, Kesanapalli Uma Venkata Subba Prabha, Maitreya Paramkusam, Sudarshan Rao Nagineni
pp. 104-114 · DOI: 10.5530/ijpi.20270098Vol. 17, Issue 1 (2027)Personalized Medicine (PM) represents a paradigm shift from the traditional “one-size-fits-all” approach to personalized preventive, diagnostic, and treatment regimens tailored to individual genetic, biological, environm…
Review ArticlePublished: 16 Oct 2026
A Ashvil, Diya Kiran, Lenora Katherine Crasto, C G Deepak, Mariyammathul Afeeza, Bipin Shaji, Shivaprasad Sirimalla, Allen Pinto, Uday Venkat Mateti, Shrinivasa Undaru Bhat, Juno Jerold Joel
pp. 115-120 · DOI: 10.5530/ijpi.20270111Vol. 17, Issue 1 (2027)Although pharmacotherapy is a cornerstone in effectively managing mood fluctuations in bipolar disorder, adherence to prescribed medications often remains a challenge in the long run, to prevent recurrent episodes and ho…
Review ArticlePublished: 16 Oct 2026
Amit Anand, Aparna Inamdar, Bannimath Gurupadayya, Kushala Reddy, Mansi Sharma, Mohit Sharma, Arindam Kolay, Dipayan Rath, Romi Kumari Thakur, Himanshu Sharma
pp. 121-137 · DOI: 10.5530/ijpi.20270136Vol. 17, Issue 1 (2027)Skin cancer remains one of the most prevalent malignancies worldwide, and delayed diagnosis often leads to poor clinical outcomes. Recent advances in Artificial Intelligence (AI), particularly deep learning and computer …
Review ArticlePublished: 16 Oct 2026
NS Preetham, Sarath Mundra, M Shreeja, R Gagan, Gayathri Karnam, Akhilesh Dubey
pp. 138-149 · DOI: 10.5530/ijpi.20270139Vol. 17, Issue 1 (2027)Regulatory agencies have developed expedited drug approval pathways to accelerate patient access to therapies addressing unmet medical needs, particularly in oncology and rare diseases. The European Medicines Agency (EMA…
Review ArticlePublished: 16 Oct 2026
Preet Tyagi, Satyam Rajput, Khushi Shrivastava, Sakshi Chaudhary, Aditya Vikram Jain, Preeti Yadav
pp. 150-154 · DOI: 10.5530/ijpi.20270180Vol. 17, Issue 1 (2027)Flame photometry is a sensitive technique for estimating alkali metals in pharmaceuticals and herbal extracts. It works on thermal excitation in a flame, causing desolvation, atomization, dissociation, and emission of li…
Review ArticlePublished: 1 Jan 2027
Mohammed Arfath Mysore Ismail, Lokesh Panjini Gopal Krishna, Muhammed Nufaiz Khalid, Akhilesh Dubey, Manohar Mahadev
pp. 155-167 · DOI: 10.5530/ijpi.20270226Vol. 17, Issue 1 (2027)Phytosome technology has transformed the delivery of plant-based bioactives by effectively addressing issues such as poor solubility, instability, and limited oral absorption. Unlike traditional lipid carriers, phytosome…
Review ArticlePublished: 16 Oct 2026
Harini Vinayagam, Ritikasri Venkatraju, Sneha Raja, Jayasutha Jayram, Sujatha Kuppusamy, Divya Varshini Natarajan, Rajeswari Jagadeesan, Janeviennygrace, Roshini Nivetha, Sudharshan Antony Raj, Nandhakumar Kannan, Sruthika Natarajan
pp. 168-176 · DOI: 10.5530/ijpi.20270199Vol. 17, Issue 1 (2027)Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, with insulin resistance and hyperinsulinemia playing key roles in its development. Although metformin is widely used to impr…
Review ArticlePublished: 16 Oct 2026
Yang Yang, Tiefeng Jin, Xiangshan Ren, Junjie Piao, Xianchun Zhou, Aihua Jin, Songnan Zhang, Zhenhua Lin
pp. 177-188 · DOI: 10.5530/ijpi.20270231Vol. 17, Issue 1 (2027)In the context of rapid transformations in healthcare systems and medical knowledge, contemporary medical education faces increasing demands to cultivate physicians who are not only clinically competent but also innovati…
Review ArticlePublished: 16 Oct 2026
Yokesh Shanmugam, Sambasivam Gopinath, Bhagyashree Annadurai, Saroj Kumari Sanjay Kumar, Dharshini Jaisankar Hindumathi, Ramya Govindarajulu, Sam Jebaraj, Dravid Raghul, Aswini Sreenivasan, Maha Vidya Gnanamani, R Abdur Rahman, Kaniga Pandi
pp. 189-206 · DOI: 10.5530/ijpi.20270252Vol. 17, Issue 1 (2027)Proteolysis-Targeting Chimeras (PROTACs) have revolutionized small-molecule pharmacology by harnessing the ubiquitin-proteasome system to achieve catalytic, event-driven degradation of disease-associated proteins rather …
Original Article
Original ArticlePublished: 16 Oct 2026
Hamza Kutty Pottengal, Prasanth Viswanadhan Vasantha, Rakeshkumar Jat
pp. 207-214 · DOI: 10.5530/ijpi.20270006Vol. 17, Issue 1 (2027)Background: The innovative analytical quantification of lupus medication Voclosporin was developed by HPLC, and HPTLC was abetted by the Ultra Violet spectroscopic method using the QbD approach. Materials and Methods: Th…
Original ArticlePublished: 16 Oct 2026
Mehdi Fathima, Deepak Kumar Jha, Saroj Kumar Sah, Soham Bhattacharjee
pp. 215-223 · DOI: 10.5530/ijpi.20270254Vol. 17, Issue 1 (2027)Aim and Objectives: Around 20% of diabetic patients are at increased risk of chronic foot ulcers. Current treatments mainly focus on glycemic control and supportive care, with limited effectiveness. Mononuclear Cell (MNC…
Original ArticlePublished: 16 Oct 2026
Shaik Parveena Ferdhoz, Naga Srinivasa Reddy Durgempudi, Pavan Kumar Yanamadala, Ramya Athina, Hima Varshini Korrapati, Harish Kakani, Jyothika Mandava, Triveni Yeddu, Anjali Chokka, Rama Rao Nadendla, Pallavi Vadlamudi
pp. 224-231 · DOI: 10.5530/ijpi.20270256Vol. 17, Issue 1 (2027)Background: Non-Communicable Diseases (NCDs) are increasingly driven by lifestyle and occupational factors, particularly in academic environments where staff experience varying workloads, sedentary patterns, and role-spe…