International Journal of Pharmaceutical Investigation · Archive
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In this issue
Original Research Article
Original Research ArticlePublished: 16 Dec 2016
Smita Raghuvanshi, Kamla Pathak
pp. 181-193 · DOI: 10.4103/2230-973X.195923Vol. 6, Issue 4 (2016)Introduction: The study was aimed at the development of low-density gastroretentive bioadhesive microsponges of cinnarizine by two-pronged approach (i) coating with bioadhesive material and (ii) exploration of acconon MC…
Original Research ArticlePublished: 16 Dec 2016
Krishnamoorthy Venkateskumar, Subramani Parasuraman, Raju Gunasunderi, Krishnan Sureshkumar, M. Muralidhar Nayak, Syed Adnan Ali Shah, Khoo Kassen, Heng Wei Kai
pp. 194-200 · DOI: 10.4103/2230-973X.195925Vol. 6, Issue 4 (2016)Objective: The objective of this study is to provide a mechanistic insight into solubility enhancement and dissolution of acyclovir (ACY) by polyethylene glycol20000 (PEG20000). Materials and Methods: Solid dispersions w…
Original Research ArticlePublished: 16 Dec 2016
Formulation development and evaluation of zolmitriptan oral soluble films using 22 factorial designs
Poluri Koteswari, G. Puja Sravanthi, M. Mounika, S. K. Mohammed Rafi, K. Nirosha
pp. 201-206 · DOI: 10.4103/2230-973X.195927Vol. 6, Issue 4 (2016)Objective: The present investigation involves the development of zolmitriptan oral soluble film (OSF) formulations and optimization with quality by design (QBD) using natural polymers and evaluation. Materials and Method…
Original Research ArticlePublished: 16 Dec 2016
Nilima A. Thombre, Ajit V. Vishwakarma, Trupti S. Jadhav, Sanjay J. Kshirsagar
pp. 207-217 · DOI: 10.4103/2230-973X.195930Vol. 6, Issue 4 (2016)Background: To formulation and development of plasma volume expander (PVE) by using natural and modified starch from Solanum tuberosum. The function of blood circulation is to provide the needs of the body tissues and to…
Original Research ArticlePublished: 16 Dec 2016
Naveen Kanthamneni, Satyanarayana Valiveti, Mita Patel, Heather Xia, Yin‑Chao Tseng
pp. 218-224 · DOI: 10.4103/2230-973X.195931Vol. 6, Issue 4 (2016)Introduction: The majority of drugs obtained through synthesis and development show poor aqueous solubility and dissolution velocity, resulting in reduced bioavailability of drugs. Most of these problems arise from formu…
Original Research ArticlePublished: 16 Dec 2016
Guo Huimin, Fu Xiaoying, Du Hongwei, Cong Wei, Meng Xiangcai
pp. 225-230 · DOI: 10.4103/2230-973X.195932Vol. 6, Issue 4 (2016)Introduction: The quality of radix scutellariae is particularly associated with environmental stresses, but detailed mechanisms remained unclear. Plant under unfavorable situation generates redundant reactive oxygen spec…
Original Research ArticlePublished: 16 Dec 2016
Jafar Fattahi‑asl, Mojtaba Karbalaee, Masoud Sanatizadeh, Payam Amini
pp. 231-237 · DOI: 10.4103/2230-973X.195933Vol. 6, Issue 4 (2016)Objective: The aim of this study was to compare the effects of radiofrequency radiation (RF) in synergism with gold (Au) and silver (Ag) nanoparticles (NPs) on the survival fraction of human normal kidney (HNK) and human…
Original Research ArticlePublished: 16 Dec 2016
N. Arjun, D. Narendar, K. Sunitha, K. Harika, B. Nagaraj
pp. 238-246 · DOI: 10.4103/2230-973X.195951Vol. 6, Issue 4 (2016)Purpose: Osmotic devices are the most promising strategy-based systems for controlled drug delivery. By optimizing formulation and processing parameters, possible to develop osmotic systems to deliver drugs at predetermi…