International Journal of Pharmaceutical Investigation · Archive
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In this issue
21–40 of 40Original Article(continued)
Original ArticlePublished: 23 Oct 2025
Rajesh Hadia, Nishi Sheth, Deep Patel, Vidhi Saparia, Ronak Shah, Hemrajsingh Rajput, Arti Shah
pp. 193-200 · DOI: 10.5530/ijpi.20260309Vol. 16, Issue 1 (2025)Background: Over 300 million people are affected worldwide with asthma. Asthma, COPD and TOPD are respiratory disorders of chronic inflammatory illness causing bronchial hyperactivity. eHealth applications are widely us…
Original ArticlePublished: 23 Oct 2025
Jyoti Tangde, Sanjay Sawant
pp. 201-209 · DOI: 10.5530/ijpi.20260313Vol. 16, Issue 1 (2025)Objectives: The present research work focuses on development and validation of Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) for the estimation of alectinib with force degradation study based on Quality …
Original ArticlePublished: 23 Oct 2025
Dharshini Jaisankar Hindumathi, Jubilee Ramasamy, Deepika Jothibasu, Niranjani Ravikumar, Binoy Varghese Cheriyan, Kaniga Pandi
pp. 210-224 · DOI: 10.5530/ijpi.20260318Vol. 16, Issue 1 (2025)Background: Nanoparticles are nanoscale materials that are well known for their distinct physical and chemical characteristics. Owing to their tiny size and special characteristics, nanoparticles such as zinc oxide nanop…
Original ArticlePublished: 23 Oct 2025
Srajana Shetty, Rakshita Paladi, Sachin Basavaraj, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanath Swamy, Latha Maregouda Goudar, Sai Sowmya Bhupathiraju, Shruti Achyut Khandke, Arpita Ravindra Walvekar, Shreya Salgare, Nida Khanum Sirdesai
pp. 225-231 · DOI: 10.5530/ijpi.20260322Vol. 16, Issue 1 (2025)Background: Cardiovascular Disease (CVD) is a general term for conditions affecting the heart or blood vessels. Globally, CVDs are the primary cause of morbidity and mortality. Frequently, treating CVDs requires intricat…
Original ArticlePublished: 23 Oct 2025
Pooja Anil Nikam, Shabnam Babu Shaikh, Girish Ravindra Kokate, Vanita Baban Katore, Saiprasad Vasant Wani, Sabafarin Hasin Shaikh, Rohit Jaysing Bhor
pp. 232-240 · DOI: 10.5530/ijpi.20260371Vol. 16, Issue 1 (2025)Background: The purpose of this work is to use Lipinski's rule to perform molecular docking and drug-likeness analysis of the proposed 5,5-diphenylimidazolidine-2,4-dione. One description claims that the most common chro…
Original ArticlePublished: 23 Oct 2025
Vivek Nilkanth Patil, Shashikala Chanmallappa Wali, Manjula Gudhoor, Pratiksha N Kini, Madiwalayya Shivakantayya Ganachari, Vishwa Rajakumar Byakod
pp. 241-251 · DOI: 10.5530/ijpi.20260387Vol. 16, Issue 1 (2025)Background: Recurrent seizures characterize epilepsy, affecting 50 million globally, with 12 million in India. Prevalence rates in North India are 6.99 per 1,000 in rural areas and 5.48 in urban areas. Medication errors …
Original ArticlePublished: 23 Oct 2025
Ajay Pakalapati, Ranganadha Reddy Aluru, Prateeksha Gupta, Charita Yejju
pp. 252-260 · DOI: 10.5530/ijpi.20260404Vol. 16, Issue 1 (2025)Objectives: Monoclonal antibodies are prone to aggregate formation at elevated temperatures due to the disruption of their native conformation resulting in protein denaturation, disulphide linkage disruptions and eventua…
Original ArticlePublished: 23 Oct 2025
Nandula Lavanya, Rashmi Nelligare Gopala krishna
pp. 261-271 · DOI: 10.5530/ijpi.20260431Vol. 16, Issue 1 (2025)Background: Duloxetine, a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), is commonly prescribed for major depressive disorder. Being a chiral compound, it exists as (R)- and (S)-enantiomers, which may exhibit distin…
Original ArticlePublished: 23 Oct 2025
Sharada Laxman Deore, Ram Chhatrapati Vighne, Bhushan Arun Baviskar
pp. 272-282 · DOI: 10.5530/ijpi.20260458Vol. 16, Issue 1 (2025)Background: The aim of the current investigation is to develop a microemulsion of bioactive enriched fractions of Indian traditional medicinal plants Bacopa monnieri and Centella asiatica to enhance neuroprotective effic…
Original ArticlePublished: 23 Oct 2025
Harshavardhan Patil, Geetanjali Salimath, Mallikarjun Karishetti, Ifraa Wariman
pp. 290-296 · DOI: 10.5530/ijpi.20260413Vol. 16, Issue 1 (2025)Background: Chronic Kidney Disease (CKD) significantly impacts QOL through physical, Psychological, and social challenges. This study explores the use of WHOQOL-BREF to assess QOL in dialysis and non-dialysis patients ac…
Original ArticlePublished: 23 Oct 2025
Sharmishta Reddipalli, Madhan Kumar Srinivasan, Lalitha Vaidyanathan
pp. 302-308 · DOI: 10.5530/ijpi.20260475Vol. 16, Issue 1 (2025)Background: The study explores the impact of limonin-induced hepatotoxicity and anxiety in adult zebrafish. Limonin is a chemical compound found in Citrus fruits and seeds, known for its biological properties. Materials …
Original ArticlePublished: 23 Oct 2025
Padmaveer Puthiyidam Sreenikakumar, Sandeep Subash Sagare, Swasthik, Vidya Parasappa Gani
pp. 309-315 · DOI: 10.5530/ijpi.20260425Vol. 16, Issue 1 (2025)Background: Gastroesophageal Reflux Disease (GERD) is a prevalent gastrointestinal disorder that significantly impacts quality of life. Occupational factors such as irregular work schedules, stress, and dietary habits co…
Original ArticlePublished: 23 Oct 2025
Gangireddy Ramana Reddy, Kunderu Ravi Shankar, Shaik Aminabee, Ravulapati Anusha, Komanduri Venkata Nagaraja, Borra Haindavi, Shaik Ramitunnisa, Rayavarapu Sanjay Babu, Pothuri Srinivasa Eswar, Koppula Jyothi
pp. 324-329 · DOI: 10.5530/ijpi.20260478Vol. 16, Issue 1 (2025)Background: The aim of this work was to develop a mouth dissolving film containing Escitalopram oxalate, utilizing basic ingredients such as polymers, plasticizers, sweeteners, saliva-stimulating agents, and flavors, to …
Original ArticlePublished: 23 Oct 2025
M J S Twinkle, K Anjali Anand, Nisha Rajesh, Jeslin Maria George, Bipin Shaji, Krishnapriya Radhakrishnan, Shraddha Shetty, Juno Jerold Joel
pp. 330-335 · DOI: 10.5530/ijpi.20260487Vol. 16, Issue 1 (2025)Background: Menopause is the permanent cessation of menstruation, marked by fluctuating estrogen, irregular periods, sleep disturbances, and various physiological and psychological difficulties. The current study was car…
Original ArticlePublished: 23 Oct 2025
Anushree Shrikant Deshpande, Madiwalayya Shivakantayya Ganachari
pp. 336-348 · DOI: 10.5530/ijpi.20260495Vol. 16, Issue 1 (2025)Background: Diabetes Mellitus (DM) is a long-term health condition that can greatly impact Health-Related Quality of Life (HRQOL), especially in women, who often encounter specific difficulties in managing the disease. O…
Original ArticlePublished: 23 Oct 2025
Balakrishna Talamanchi, Venkateswara Rao Javvaji, Lakshman Kumar Dogiparthi, Jayanth Babu Sajja, Sai Sruthi Nimmagadda, Vijaya Preethi Parasa, Pavan Ramakrishna Tadikonda, Sabreen Shaik, Fahamida Shaik, Raheema Shaik
pp. 349-356 · DOI: 10.5530/ijpi.20260544Vol. 16, Issue 1 (2025)Introduction: The main purpose of zolmitriptan fast-dissolving films aims to deliver zolmitriptan effectively alongside quick action for migraine therapy through a user-friendly dosage method. Fast dissolving films disso…
Original ArticlePublished: 23 Oct 2025
Bhuvaneshwari Sharannavar, Apurva Deo, Shailendra Suryawanshi, Parixit Bhandurge, Nithyanand Sastry Darbha
pp. 357-370 · DOI: 10.5530/ijpi.20261680Vol. 16, Issue 1 (2025)Background: A new stability-indicating Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method was developed to quantify Darunavir (DRV), an HIV-1 protease inhibitor, despite its limited water solubility a…
Research Article
Research ArticlePublished: 23 Oct 2025
Sneha Chacko, Gaurang Shah
pp. 283-289 · DOI: 10.5530/ijpi.20260451Vol. 16, Issue 1 (2025)Background: The 6-Min Walk Distance (6MWD) test is widely used to assess functional capacity in respiratory patients, but response patterns across different respiratory conditions remain poorly understood. Materials and …
Research ArticlePublished: 23 Oct 2025
Jyoti Sahu, Jisha Joseph, Vipul Alias Parab, Neeta Rai, Amit Lunkad, Pritam Bhore, Kirti Deshpande, Pallavi Kale, Ravi Kumar Sah, Jayesh Baldota
pp. 297-301 · DOI: 10.5530/ijpi.20260457Vol. 16, Issue 1 (2025)Objectives: This research focused on formulating and assessing a silica-based herbal emulgel enriched with antimicrobial and anti-inflammatory agents, including tulsi (Ocimum sanctum) and neem (Azadirachta indica) oils, …
Research ArticlePublished: 23 Oct 2025
Kapil Kulkarni, Gitanjali Deokar
pp. 316-323 · DOI: 10.5530/ijpi.20260456Vol. 16, Issue 1 (2025)Introduction: Lisinopril HCl (LH) and Carvedilol Phosphate (CP) combination bilayer tablet to be developed for the treatment of hypertension. Objectives: To develop carvedilol phosphate and lisinopril hydrochloride bilay…