International Journal of Pharmaceutical Investigation · Archive
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In this issue
21–36 of 36Original Article(continued)
Original ArticlePublished: 30 Jun 2024
Arram Madhavi, Medidi Srinivas, Niraj Gupta
pp. 822-832 · DOI: 10.5530/ijpi.14.3.92Vol. 14, Issue 3 (2024)Objectives: A simple and sensitive analytical method was developed to quantify the vericiguat in tablet formulation. Materials and Methods: The analyte was separated on a Kromacil C column (250 mm×4.6 mm×5 μm particle si…
Original ArticlePublished: 30 Jun 2024
Daneshwari Bhusannavar, Bhuvneshwari Sharannavar, Nithyananda Sastry Darbha, Shailendra Suryawanshi, Sarvesh Patil, Parixit Bhandurge
pp. 833-842 · DOI: 10.5530/ijpi.14.3.93Vol. 14, Issue 3 (2024)Background: The primary objective of this study is to pioneer a novel UV spectrophotometric method, designed with simplicity and high sensitivity to accurately measure both Rutin and Curcumin simultaneously. Rutin has a …
Original ArticlePublished: 30 Jun 2024
Sankaranarayanan Vijayalakshmi, Somaskandan Subramanian, Sellappan Malathi
pp. 843-850 · DOI: 10.5530/ijpi.14.3.94Vol. 14, Issue 3 (2024)Background: 5-Fluorouracil (5-FU) is a chemotherapy drug commonly used in the treatment of colon cancer. There is a significant drive to mitigate the limitations of 5-fluorouracil while maintaining its therapeutic potenc…
Original ArticlePublished: 30 Jun 2024
Shamjetshabam Babeeta Chanu, Laishram Rupachandra Singh, Sanjenbam Kunjeshwori Devi, Sanasam Yaiphabi, Birson Ingti, Taranga Jyoti Baruah
pp. 851-856 · DOI: 10.5530/ijpi.14.3.95Vol. 14, Issue 3 (2024)Background: Tyrosinase is an enzyme involved in the production of L-DOPA. To look for novel tyrosinase inhibitors, we investigated the non-protein fraction from the sericin extract of the silk cocoon shell of Antheraea p…
Original ArticlePublished: 30 Jun 2024
Balaji Rathnam Kamalarathnam, Vadivelan Panneerselvam Karthik, Parvathreddy Sowmya, Kavitha Ramasamy
pp. 857-872 · DOI: 10.5530/ijpi.14.3.96Vol. 14, Issue 3 (2024)Background: Lung cancer is the most reported cancer worldwide and therapeutic resistance poses a major challenge. This in silico molecular docking and molecular dynamic simulation study was carried out to evaluate the bi…
Original ArticlePublished: 30 Jun 2024
Narayanamma Lakshmi Mudunuru, Kalyan Chakravarthy Janjanam, Rajeswari Saripilli
pp. 873-880 · DOI: 10.5530/ijpi.14.3.97Vol. 14, Issue 3 (2024)Background: Diabetic mellitus is the oldest and most commonly occurring disease known as a life-threatening disease in all age groups from the past 3000 years ago, which is taking away the liveliness from the persons and…
Original ArticlePublished: 30 Jun 2024
Adhithyanarayana Bhat Kodangodlu Subhramanya, Prashant Nayak, Harshitha Ramalingappa, Harish Kachcharavi Hemanna, Prerana Shetty
pp. 881-887 · DOI: 10.5530/ijpi.14.3.98Vol. 14, Issue 3 (2024)Background: This study presents a comprehensive study on applying the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Q1A R2 guideline for conducting stability tests on…
Original ArticlePublished: 30 Jun 2024
Megha Ganesh Bhise, Lima Patel, Khyati Patel
pp. 888-902 · DOI: 10.5530/ijpi.14.3.99Vol. 14, Issue 3 (2024)Background: 3D printing, also known as additive manufacturing, is a rapidly advancing technology in the life sciences sector. Several countries, including the USA, Canada and Singapore, have established regulations for 3…
Original ArticlePublished: 30 Jun 2024
Mrunalini Devi Kotagiri, Shiva Kumar Gubbiya
pp. 903-914 · DOI: 10.5530/ijpi.14.3.100Vol. 14, Issue 3 (2024)Background: Alzheimer’s Disease (AD) is the most prevalent cause of dementia globally and its frequency increases as the world’s population ages. AD is one of the largest healthcare issues of the 21st century as the prim…
Original ArticlePublished: 30 Jun 2024
Krantisinha Hanumant Randive, Meenaxi Maruti Maste, Amolkumar Ashok Kempwade
pp. 915-927 · DOI: 10.5530/ijpi.14.3.101Vol. 14, Issue 3 (2024)Background: Nebivolol hydrochloride (NBV) is a highly selective beta-adrenoceptor antagonist belonging to the third generation of beta-blockers. It is primarily utilized in the management of cardiovascular conditions. Si…
Original ArticlePublished: 30 Jun 2024
Kavin Panneerselvam, Subramanian Somaskanthan
pp. 928-934 · DOI: 10.5530/ijpi.14.3.102Vol. 14, Issue 3 (2024)Background: Miconazole nitrate, a BCS class II drug which is used for treatment of fungal infections. To minimize the disadvantages of sticky creams and ointments and their tendency to rub off, an intelligent dosage regi…
Original ArticlePublished: 30 Jun 2024
Mahek Shah, Lajja Patel, Shailvi Shah, Khushali Parekh, Mohit Shah, Dhaivat Parikh, Tejal Mehta
pp. 935-945 · DOI: 10.5530/ijpi.14.3.103Vol. 14, Issue 3 (2024)Background: Gout is a chronic disease caused by the accumulation of uric acid crystals in joints, resulting in sudden pain, stiffness, and swelling. Febuxostat (FBX), a xanthine oxidase inhibitor, is commonly used to tre…
Original ArticlePublished: 30 Jun 2024
Mohini Rawat, G. Gnanarajan
pp. 946-958 · DOI: 10.5530/ijpi.14.3.104Vol. 14, Issue 3 (2024)Background: The most popular and well-designed nano-carriers for drug delivery targeting are liposomes. In order to overcome barriers to cellular and tissue uptake and increase medication bio-distribution to target areas…
Original ArticlePublished: 30 Jun 2024
Vaishnavi Vilas Galande, Mahesh Hari Kolhe, Aditi Rajendra Khatal, Rohit Jaysing Bhor, Payal Sopan Gawali, Pratibha Sudhakar Bhalerao, Manjusha Pandharinath Mhaske
pp. 959-965 · DOI: 10.5530/ijpi.14.3.105Vol. 14, Issue 3 (2024)Aim: Vildagliptin and Dapagliflozin in fixed-dose combination is used for treatment of Type II Diabetes Mellitus. The key objective of the current research work is to develop a new stability-indicating UHPLC method for t…
Original ArticlePublished: 30 Jun 2024
Pallavi Patil, Sandhya Bagde, Kalyani Kalad, Varsha Pawar, Neha Shegokar, Sakshi Bharti
pp. 966-979 · DOI: 10.5530/ijpi.14.3.106Vol. 14, Issue 3 (2024)Background: Studies have indicated that atazanavir is prone to degradation in environments with high levels of acidity and oxidative stress. However, the drug demonstrated stability when exposed to basic, neutral, photol…
Case Report
Case ReportPublished: 30 Jun 2024
Megha Hegde, Saurav Raj, Dhananjay Tikadar, Sanatkumar Bharamu Nyamagoud, Suhana Nawab, Muskan Padgutti, Musharraf Chandsha
pp. 980-982 · DOI: 10.5530/ijpi.14.3.107Vol. 14, Issue 3 (2024)Background: The side effect of Parkinsonism due to chlorpromazine emerged three years after its approval for public use, leading to the understanding that conventional anti-psychotics could induce various Extrapyramidal …