International Journal of Pharmaceutical Investigation · Archive
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In this issue
21–40 of 47Original Article(continued)
Original ArticlePublished: 16 Oct 2026
Ramalingam Gomathi, Thirupambaram Nataraja Sundaram Uma Maheswari, Shanmugam Rajesh Kumar
pp. 232-237 · DOI: 10.5530/ijpi.20270007Vol. 17, Issue 1 (2027)Background: Chronic inflammation and oxidative stress lead to tissue damage, resulting in heightened interest in plant-based therapeutics with low toxicity. Sesame and raspberry contain bioactive compounds that are both …
Original ArticlePublished: 16 Oct 2026
Sonika Shrivastav, Kamal Singh Rathore, Dinesh Kumar Yadav, Phool Chandra, Arvind Raghav, Neetu Sachan
pp. 238-248 · DOI: 10.5530/ijpi.20270015Vol. 17, Issue 1 (2027)Background: Major depressive disorder is a heterogeneous disease that primarily contributes to global disability. In this condition, individuals often experience disturbances in sleep patterns and psychomotor functions, …
Original ArticlePublished: 16 Oct 2026
Reddy Prasad Chowdareddy, Thirunavukkarasu Jayaraman, Afzal Khan AK, Mohanakrishna Ghanta, Bibi Umeza
pp. 249-255 · DOI: 10.5530/ijpi.20270024Vol. 17, Issue 1 (2027)Objectives: Pomegranate (Punica granatum) is a well-known source of bioactive phytochemicals, particularly punicalagin, which contributes to its antioxidant, anti-inflammatory, and antimicrobial properties. Materials and…
Original ArticlePublished: 16 Oct 2026
Jitendra Kantilal Chordiya, Ujashkumar Shah, Nidhi Shah
pp. 256-268 · DOI: 10.5530/ijpi.20270050Vol. 17, Issue 1 (2027)Background: The Multi unit-controlled release dosage forms is a drug delivery system offering advantage over traditional monolithic controlled release system in achieving persistent and predictable drug delivery. Multipl…
Original ArticlePublished: 16 Oct 2026
Jigneshkumar Varu, Pradeep Shahajirao Shindhe, Ramesh Shivappa Killedar, Aniket Ughade
pp. 269-275 · DOI: 10.5530/ijpi.20270060Vol. 17, Issue 1 (2027)Introduction: In Ayurveda, Allium sativum (Lashuna) has been described in great detail as a Medhya medication that may improve cognitive function. The current study used molecular docking and in silico network pharmacolo…
Original ArticlePublished: 16 Oct 2026
Shalam Mohamed Hussain, Nayef Almutairi, Fahad Alrakaf, Mohammed Aljameli
pp. 276-282 · DOI: 10.5530/ijpi.20270064Vol. 17, Issue 1 (2027)Background: Alzheimer’s disease affecting about 18 million people world-wide. The socio-economic burden on world-economies costing more than 172 billion US $ annually for the US alone. Objectives: To prepare aqueous extr…
Original ArticlePublished: 16 Oct 2026
Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju
pp. 283-291 · DOI: 10.5530/ijpi.20270083Vol. 17, Issue 1 (2027)Background: Epilepsy is a chronic neurological disorder characterized by recurrent seizures caused by abnormal electrical activity in the brain. The development of novel anticonvulsant agents with improved efficacy and s…
Original ArticlePublished: 16 Oct 2026
Tuba Türkoğlu, Semra Türkoğlu
pp. 292-299 · DOI: 10.5530/ijpi.20270108Vol. 17, Issue 1 (2027)Background: Verbascum diversifolium, an endemic medicinal plant native to Türkiye, is recognized for its potential therapeutic and economic value. This study aimed to evaluate the antimicrobial, antioxidant, total phenol…
Original ArticlePublished: 16 Oct 2026
Yuanchao Kang, Shizhe Chen, Yanwen Hao, Yan Lin
pp. 300-309 · DOI: 10.5530/ijpi.20270131Vol. 17, Issue 1 (2027)Background: Adverse Drug Reactions (ADRs) severely affect clinical medication safety, and the Pareto principle is widely applied to identify key risk factors in pharmacovigilance. Systematic retrospective analysis of hos…
Original ArticlePublished: 16 Oct 2026
Mitali Milind Bodhankar, Shrushti Soitkar, Snehal Shrivastav, Shubham Gupta, Pranali Band
pp. 310-321 · DOI: 10.5530/ijpi.20270132Vol. 17, Issue 1 (2027)Background/Objectives: Cutaneous candidiasis remains a significant clinical challenge, particularly in warm, moist body regions and immunocompromised individuals. This study focuses on the development and evaluation of a…
Original ArticlePublished: 16 Oct 2026
Hema Barti, Krishana Kumar Sharma
pp. 322-328 · DOI: 10.5530/ijpi.20270134Vol. 17, Issue 1 (2027)Background: Hepatocellular Carcinoma (HCC) is a common and highly aggressive form of cancer worldwide. Oxidative stress is closely associated with the development and progression of HCC. An excessive increase in Reactive…
Original ArticlePublished: 16 Oct 2026
Priyanka Shah, Riya Patel, Shreeraj Shah
pp. 329-337 · DOI: 10.5530/ijpi.20270173Vol. 17, Issue 1 (2027)Background: Stress management remains a significant therapeutic challenge, necessitating the development of novel delivery systems that enhance patient adherence. This research presents the formulation and characterizati…
Original ArticlePublished: 16 Oct 2026
Ladi Alik Kumar, Gurudutta Pattnaik, Himansu Bhusan Samal, K Naga Jogayya, Chandra Sekhar Patro, Gopal Krishna Padhy
pp. 338-344 · DOI: 10.5530/ijpi.20270206Vol. 17, Issue 1 (2027)Background: Metronidazole is a commonly prescribed nitroimidazole antibiotic for Bacterial Vaginosis (BV), rosacea, periodontal infections, and other anaerobic or protozoal infections. However, conventional topical dosag…
Original ArticlePublished: 16 Oct 2026
Yan-Ling Wu, Cui Zhen-Yu
pp. 345-349 · DOI: 10.5530/ijpi.20270219Vol. 17, Issue 1 (2027)Background: As an important discipline in medicine and pharmacy, pharmacology teaching needs constant improvement to adapt to social demands and technological developments. This study proposes suggestions based on “speci…
Original ArticlePublished: 16 Oct 2026
Amani Alharthi
pp. 350-361 · DOI: 10.5530/ijpi.20270225Vol. 17, Issue 1 (2027)Background: Lung carcinoma is one of the most important health problems in the world and there is a need to develop effective and less toxic therapeutic agents. Computational drug discovery is an efficient approach for d…
Original ArticlePublished: 16 Oct 2026
Chun-Mei Wang, Bo Shen, Chen-Yan Xu, Jing Zhang, Lu Yang, Ren-Zheng Huang, Hua Chen
pp. 362-372 · DOI: 10.5530/ijpi.20270229Vol. 17, Issue 1 (2027)Background: Dihydroartemisinin (DHA), a well-established antimalarial agent has been increasingly recognized for its antiviral and antitumor effects across multiple diseases. However, the potential effects of DHA on Non-…
Original ArticlePublished: 16 Oct 2026
Varsha Mugundhan, Priyangha Ponmudi Thangavel
pp. 373-380 · DOI: 10.5530/ijpi.20270230Vol. 17, Issue 1 (2027)Background: Artificial sweeteners are widely used as non-cariogenic alternatives to dietary sugars, and beyond their sweetening properties, certain sweeteners have demonstrated antimicrobial activity, suggesting potentia…
Original ArticlePublished: 1 Jan 2026
Pranay Kumar Ravula, Lakshmi Manogna Parupudi, Pravalika Pottigari, Jahnavi Bandla
pp. 381-400 · DOI: 10.5530/ijpi.20270240Vol. 17, Issue 1 (2027)Background: The widespread availability of branded and generic antidiabetic tablet formulations has increased the need for rapid, reliable, and cost-effective analytical methods to ensure their authenticity and quality. …
Original ArticlePublished: 16 Oct 2026
Vipul Kumar, Vaibhav Rastogi
pp. 401-429 · DOI: 10.5530/ijpi.20270253Vol. 17, Issue 1 (2027)Background: Amisulpride, a Biopharmaceutics Classification System (BCS) Class II antipsychotic drug, exhibits limited aqueous solubility, resulting in poor dissolution and suboptimal oral bioavailability. Self-Emulsifyin…
Original ArticlePublished: 16 Oct 2026
Pranaya Peram, Geetha Karra, Pravalika Patlolla, V Uma Maheswara Rao
pp. 430-439 · DOI: 10.5530/ijpi.20270241Vol. 17, Issue 1 (2027)Background: Chronic wounds, including diabetic ulcers, pressure ulcers, and burn injuries, are characterized by persistent infection, prolonged inflammation, and impaired tissue regeneration, making them difficult to tre…