Design and Investigation of Metformin Hydrochloride–Indion‑254 Complex for Dispersible Tablets

  • Arlene Stuart Villarroel [1]Department of Pharmacology and [2]School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, West Indies.
  • Madan Mohan Gupta [2]School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, and [3]Laboratory of Pharmaceutical Formulation Design and Development, School of Pharmacy Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
  • Lexley M. Pinto Pereira Department of Pharmacology, Faculty of Medical Sciences, The University of the West Indies,
  • Andanappa K. Gadad School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Keywords: Complex, Drug dissolution, Indion‑254, Metformin hydrochloride, Taste masking

Abstract

Objective: Metformin is a first‑line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion‑254 resin for the purpose of preparation of dispersible tablet. Materials and Methods: This study formulated metformin hydrochloride–Indion‑254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability. Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X‑ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients. Conclusion: The formulated metformin hydrochloride–Indion‑254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.

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Fourier transform‑infrared spectroscopy of metformin hydrochloride and its complex with resin.
Published
2018-07-11
How to Cite
1.
Villarroel AS, Gupta MM, Pereira LMP, Gadad AK. Design and Investigation of Metformin Hydrochloride–Indion‑254 Complex for Dispersible Tablets. ijpi [Internet]. 11Jul.2018 [cited 31Jul.2021];8(1):07-3. Available from: https://www.jpionline.org/index.php/ijpi/article/view/237