Development of a Binary Carrier System Consisting Polyethylene Glycol 4000 - Ethyl Cellulose for Ibuprofen Solid Dispersion

  • Gada Sulaiman A Alagdar Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • May Kyaw Oo Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • Pinaki Sengupta National Institute of Pharmaceutical Science and Research, Ahmedabad, India
  • Uttam Kumar Mandal Department of Pharmacy, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India
  • Julian Md Jaffri Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • Bappaditya Chatterjee Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
Keywords: Binary carrier system, Ethyl cellulose, Ibuprofen, Polyethylene glycol 4000, Solid dispersion

Abstract

Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aimed to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which was responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE> SDP> physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form.

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Microscopic images of all samples (a – c: optical microscopic image of ibuprofen, PM and SDPE respectively; d & e: SEM micrograph of ibuprofen and SDPE respectively)
Published
2017-10-17
How to Cite
1.
Alagdar GSA, Oo MK, Sengupta P, Mandal UK, Jaffri JM, Chatterjee B. Development of a Binary Carrier System Consisting Polyethylene Glycol 4000 - Ethyl Cellulose for Ibuprofen Solid Dispersion. ijpi [Internet]. 17Oct.2017 [cited 31Jul.2021];7(3):142-8. Available from: https://www.jpionline.org/index.php/ijpi/article/view/212