Threatened Ayurvedic Herb (Seeta Ashoka) Substitution Options for Menorrhagia-based on Bioactive Principle’s Molecular Docking Study

  • Utkarsh Ghate Gram Mooligai (Village herbs) Co. ltd. (GMCL), Durg, Chhattisgarh, INDIA.
  • Hema Kulkarni Govt. S. D. S. collge, Jamgao-R, Durg, Chhattisgarh, INDIA
  • Manasi Deshpande Bharati Vidyapeeth Ayurveda College, Pune, Maharashtra, INDIA.
  • Mandar Akkalkotkar Tilak Ayurveda Collage, Pune, Maharashtra, INDIA.
Keywords: Herb, Ayurveda, Menorrhagia, Polyphenol, In silico.

Abstract

Molecular docking studies are used to identify cultivated/ abundant herbs such as Coriander, Burmuda grass or Asparagus as potential replacement for Seeta Ashoka- Saraca asoca (Roxb.) De Wilde, syn. S. indica Linn. a rare Indian medicinal forest plant, threatened with extinction due to over harvest. Its bark is used to make the famous Ayurvedic medicine “Ashokarishta” to treat menorrhagia and as a uterine tonic like ergot but is mostly adulterated. We tested using molecular docking studies Quercetin and other polyphenols from Coriander as potent anti-inflammatory ingredients, similar to NSAID (Non-steroidal anti-inflammatory drugs)., Polyalthia longifolia, the common adulterant is also be noted to be effective as its bark contains 30-50% of tannin than Saraca asoca, so may help in thrombosis.

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Threatened Ayurvedic Herb (Seeta Ashoka) Substitution Options for Menorrhagia-based on Bioactive Principle’s Molecular Docking Study
Published
2022-07-26
How to Cite
1.
Ghate U, Kulkarni H, Deshpande M, Akkalkotkar M. Threatened Ayurvedic Herb (Seeta Ashoka) Substitution Options for Menorrhagia-based on Bioactive Principle’s Molecular Docking Study. ijpi [Internet]. 26Jul.2022 [cited 10Aug.2022];12(3):250-4. Available from: https://www.jpionline.org/index.php/ijpi/article/view/1347