Anti-inflammatory Activity of Chlorella vulgaris in Experimental models of Rats

Abstract

Background: The aim of present study is to evaluate the anti-inflmmatory activity of Chlorella vulgaris in acute and chronic experimental inflammatory model. Plant extract was analyzed for photochemical screening of different phytoconstituents. Methods: Paw edema was induced with 1.5% carrageenan to all the groups except normal. Diclofenac was used as a standard drug and Chlorella vulgaris at 50, 100, 200 mg/kg dose was used for study. Carrageenan was administered in the paw. Paw thickness was measured at 0, 1, 2 and 4 hr. Inflammatory cytokines and oxidative stress were measured in paw homogenate. Chronic inflammatory activity was screened by using cotton pellet induced granuloma. Results: In result, paw thickness was increased from 1 hr to 4 hr and Chlorella vulgaris treated group shows decrease in paw thickness. SOD and GSH content was decreased and MDA level increased in carrageenan injected group, however treatment groups shows reverse effects also we found that increase in cytokine level in carrageenan group and decrease in treatment group. In, egg albumin model paw volume was decreased in rats treated with Chlorella vulgaris. In chronic model CV treated group also showed dose dependent activity. Conclusion: From this study we conclude that Chlorella vulgaris has antiinflammatory activity.