Primates and Rodent Models for Dementia: A Review

  • Rahul Kumar Sharma Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab, INDIA.
  • Harsimran Singh Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab, INDIA.
  • Devinder Kaur Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab, INDIA.
  • Yogesh Kumar Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab, INDIA.
Keywords: Dementia, Animal models, Cognitive dysfunctions, Neurological dysfunction, Transgenic animal model

Abstract

Memory and cognitive functions are some of the most important and complex functions performed by the human brain. Any disorders which affect our memory will very much affect our lifestyle. Dementia and other cognitive dysfunctions are progressively emerging in the human race. To uncover newer drugs to cure such disorders we need better medium to understand the pathophysiological events occur during such disorders, so that we can make better approaches toward the cure. For such purpose different animal models are there. This review will uncover the most significant animal models. A thorough and critical evaluation of present rodent and primate models, their possible mechanism to cause such disorders and their role in drug discovery has been carried out. There are many possible pathological events that occur during cognitive disorders; in this review, we try to cover them all. This review will give a complete in-site of prognosis, progression, and evaluation of newer drugs has been made.

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Transgenic Animal Models of Dementia
Published
2021-10-13
How to Cite
1.
Kumar Sharma R, Singh H, Kaur D, Kumar Y. Primates and Rodent Models for Dementia: A Review. ijpi [Internet]. 13Oct.2021 [cited 4Dec.2021];11(3):254-9. Available from: https://www.jpionline.org/index.php/ijpi/article/view/1062