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  Indian J Med Microbiol
 

Figure 5: Effects of single oral doses of (a) quinoline derivatives and (b) letrozole on serum concentrations of cortisol and aldosterone as anin vivo aromatase selectivity assay. Male rats received a subcutaneous injection of 10 mg/kg of adrenocorticotropic hormone, and 16 h later, they were treated with 4 mg/kg of either compound 8b or letrozole (control group received normal saline). After 2 h, all animals were beheaded, and their whole blood was collected. Serum concentration of aldosterone and cortisol was measured by ELISA assay. The values are shown as mean ± standard error of the mean of determinations carried out of six rats in each group. ***P ≤ 0.001

Figure 5: Effects of single oral doses of (a) quinoline derivatives and (b) letrozole on serum concentrations of cortisol and aldosterone as an<i>in vivo</i> aromatase selectivity assay. Male rats received a subcutaneous injection of 10 mg/kg of adrenocorticotropic hormone, and 16 h later, they were treated with 4 mg/kg of either compound 8b or letrozole (control group received normal saline). After 2 h, all animals were beheaded, and their whole blood was collected. Serum concentration of aldosterone and cortisol was measured by ELISA assay. The values are shown as mean ± standard error of the mean of determinations carried out of six rats in each group. ***<i>P</i> ≤ 0.001