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  Indian J Med Microbiol
 

Figure 3: Inhibition of the androstenedione-induced uterine hypertrophy by quinoline derivatives and letrozole as an assay for the inhibition of aromatase in vivo. The immature female rats were treated with different doses of either quinoline derivatives or letrozole orally as well as IP injection of standard dose of androstenedione (30 mg/kg/day) for 4 consecutive days. Negative control group has been orally treated with olive oil, and positive control has received androstenedione. Results were expressed as uterine relative weight as a ratio of (uterine wet weight [mg]/body weight [g]) treated sample/(uterine wet weight [mg]/body weight [g]) negative control.The values are shown as mean ± standard error of the mean of determinations carried out of six rats in each group. +++P ≤ 0.001 to negative control and ***P ≤ 0.001 to positive control

Figure 3: Inhibition of the androstenedione-induced uterine hypertrophy by quinoline derivatives and letrozole as an assay for the inhibition of aromatase <i>in vivo.</i> The immature female rats were treated with different doses of either quinoline derivatives or letrozole orally as well as IP injection of standard dose of androstenedione (30 mg/kg/day) for 4 consecutive days. Negative control group has been orally treated with olive oil, and positive control has received androstenedione. Results were expressed as uterine relative weight as a ratio of (uterine wet weight [mg]/body weight [g]) treated sample/(uterine wet weight [mg]/body weight [g]) negative control<sub>.</sub>The values are shown as mean ± standard error of the mean of determinations carried out of six rats in each group. +++<i>P</i> ≤ 0.001 to negative control and ***<i>P</i> ≤ 0.001 to positive control