International Journal of Pharmaceutical Investigation

ORIGINAL RESEARCH ARTICLE
Year
: 2018  |  Volume : 8  |  Issue : 2  |  Page : 53--62

Usnic acid-loaded bioinspired heparin modified-cellulose acetate phthalate nanoparticle(s) as an efficient carrier for site-specific delivery in lung cancer cells


Ashish Garg1, Nitendra K Sahu1, Awesh Kumar Yadav2 
1 Department of Pharmaceutics, RKDF College of Pharmacy, SRK University, Bhopal, Madhya Pradesh, India
2 Department of Pharmaceutics, Drug Delivery and Nanotechnology Laboratories, Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh, India

Correspondence Address:
Dr. Awesh Kumar Yadav
Department of Pharmaceutics, Drug Delivery and Nanotechnology Laboratories, Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh
India

Introduction: The main goal of the current study was to assess the cytotoxic influence of usnic acid (UA) after enclosement in heparin modified-cellulose acetate phthalate (HEC) nanoparticles (NPs) when targeted to lung cancer A549 cell line. Materials and Methods: HEC copolymer was manufactured by precipitation method and was substantiated by Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. HEC NPs with UA was formulated by employing HEC copolymer and later competed with UA-loaded cellulose acetate phthalate (CAP) NPs. NPs were exemplified by zeta potential, differential scanning calorimetry, particle size, atomic force microscopy, in vitro release, entrapment efficiency, X-ray diffraction , and polydispersity index. Results: Studies revealed that HEC NPs have a slower release (96.21% in 32 h) when contrasted with CAP NPs (97.36% in 8 h). In cytotoxicity analysis of A549, UA-loaded HEC NPs illustrated an immense cytotoxic potential. In addition, HEC NPs were found to be more hemocompatable in comparison to CAP NPs and plain UA. Conclusion: Decisively, on account of investigational results UA-loaded HEC NPs were percieved to be more cytotoxic against lung cancer cells than UA-loaded CAP NPs and plain UA.


How to cite this article:
Garg A, Sahu NK, Yadav AK. Usnic acid-loaded bioinspired heparin modified-cellulose acetate phthalate nanoparticle(s) as an efficient carrier for site-specific delivery in lung cancer cells.Int J Pharma Investig 2018;8:53-62


How to cite this URL:
Garg A, Sahu NK, Yadav AK. Usnic acid-loaded bioinspired heparin modified-cellulose acetate phthalate nanoparticle(s) as an efficient carrier for site-specific delivery in lung cancer cells. Int J Pharma Investig [serial online] 2018 [cited 2019 Mar 21 ];8:53-62
Available from: http://www.jpionline.org/article.asp?issn=2230-973X;year=2018;volume=8;issue=2;spage=53;epage=62;aulast=Garg;type=0