Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

  • Mohd Urooj Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA
  • Gulam Mohammed Husain Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA
  • Mohd. Nadeem Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA
  • Mohammed Abdul Rasheed Naikodi Drug Standardization Research Unit, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA.
  • Mahe Alam Central Council for Research in Unani Medicine, New Delhi, INDIA.
  • Munawwar Husain Kazmi Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA
Keywords: Majoon Najah, Antiepileptic, Antidepressant, Polyherbal, Traditional medicine

Abstract

Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P<0.001) reduction in immobility duration in animals treated with majoon najah classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats. Conclusion: Based on above findings, it may be concluded that majoon najah did not showed effectiveness in epilepsy however, the results evident that majoon najah is a potential Unani formulation having antidepressant activity which may be preferred as an alternative therapy over modern medicine to treat depression.

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Densitogram of MN hydro alcoholic extract and peak listed at UV 366nm.
Published
2020-10-02
How to Cite
1.
Urooj M, Husain GM, Nadeem M, Naikodi MAR, Alam M, Kazmi MH. Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals. ijpi [Internet]. 2Oct.2020 [cited 27Oct.2020];10(3):396-01. Available from: http://www.jpionline.org/index.php/ijpi/article/view/712