Solid Lipid Nanoparticles of Sulpiride: Improvement of Pharmacokinetic Properties

  • Mahmoud Mokhtar Ibrahim 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT. 2Department of Pharmaceutics, Oman College of Health Sciences, Pharmacy Program, Ministry of Health, Muscat, OMAN.
  • Abdallah Mohamed Ayoub Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
  • Mahmoud Abd Elghany Mahdy Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
  • Marwa Helmy Abdallah 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT. 3Department of Pharmaceutics, College of Pharmacy, Hail University, Hail, KINGDOM OF SAUDI ARABIA.
Keywords: Nanoparticles, Lipid, Stearic, Sulpiride, Bioavailability, Pharmacokinetics

Abstract

Objectives: In this study, it is hypothesized that lipid carriers could enhance the pharmacokinetic behaviour of Sulpiride (Sul). Different Lipids such as Palmitic Acid (PA), Stearic Acid (SA) and triaplmitin (TA) were used to prepare Solid Lipid Nanoparticles (SLNs) which is then better characterized and tested for its in vivo bioavailability. Methods: SLNs were prepared using film homogenization technique. Different physicochemical parameters such as Homogenization Speed (HS), Homogenization Time (HT) and Sonication Time (ST) were evaluated. Surfactant type and concentration of surfactant, soy lecithin and lipid type were scrutinized. Finally, SLNs pharmacokinetic parameters were evaluated. Results: Sul Entrapment Efficiency (EE) and drug loading were highly associated with solubility in lipid and partition coefficients. The particle size was decreased with an increase in HT, HS and ST. According to lipid type, the EE was high using SA and low using TP. The EE was raised with an increment in the concentration of lipids and soy lecithin. Regarding the in vivo study, Sul SLNs showed 2.64 fold increase in relative bioavailability with higher Cmax (816.22 ng/ml) than the drug suspension form (550 ng/ml). Conclusion: SLNs are considered promising flexible carriers that can be tailored to enhance the solubility, bioavailability and the expected therapeutic response of poorly soluble drugs.

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Effect of lipid type and lipid concentration (LC) on EE (A), DL
Published
2019-11-05
How to Cite
1.
Mokhtar Ibrahim M, Ayoub A, Mahdy M, Abdallah M. Solid Lipid Nanoparticles of Sulpiride: Improvement of Pharmacokinetic Properties. ijpi [Internet]. 5Nov.2019 [cited 13Nov.2019];9(3):122-7. Available from: http://www.jpionline.org/index.php/ijpi/article/view/408