Antidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat

  • Binish Inam Department of Community Medicine, Narayan Medical College and Hospital, Jamuhar, Sasaram-Rohtas, Bihar, INDIA.
  • Adil Inam Department of Community Medicine, Narayan Medical College and Hospital, Jamuhar, Sasaram-Rohtas, Bihar, INDIA.
  • Monika Verma Department of Paediatrics, Advanced Paediatrics Centre - PGIMER, Chandigarh, Punjab, INDIA.
  • Kamlesh Kumar Naik Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Perundurai, Main Road, Erode, Tamil Nadu, INDIA.
  • Afroze Alam [4]Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Rohtas (Sasaram), Bihar, INDIA. [5]School of Pharmacy, Al-Karim University, Katihar-Purnia Road, Sirsa, Karim Bagh, Katihar, Bihar, INDIA.
Keywords: Antidiabetic activity, Creatinine, Flavones, Total Protein, SGOT, SALP, SGPT, Streptozotocin

Abstract

Objectives: The objective of the study was to develop new antidiabetic agents from synthetic route. Methods: An attempt was made to synthesize various flavones. The structures of the compounds were elucidated by UV, IR, 1H-NMR and mass spectrometry. Furthermore, an in vivo antidiabetic activity study was carried out by streptozotocin induced model. Biochemical parameters were extensively studied to support antidiabetic potential of synthesized flavones. Results: The study reveals that flavones such as F1, F2, F3, F5 and F8 were potentially considered for in-vivo antidiabetic activity. Fasting blood glucose and biochemical parameters like total protein, urea and creatinine, SGOT, SALP and SGPT were performed for the biological evaluation and compared with that of standard glibenclamide (5 mg/kg). Among the five consolidated flavones, F8 possess high significant (p < 0.01) results and restores the blood glucose level, liver enzymes and renal parameters. Based on these results, a promising potent drug would be developed in the management of diabetes mellitus. Conclusion: In-vivo evaluations of selected compounds were carried out for its antidiabetic activity considering different biochemical parameters. Some of the selected flavones showed excellent and noticeable antidiabetic activity.

Downloads

Download data is not yet available.
Figure 1: Effect of synthesized flavones on BGL in Diabetic rats.
Published
2019-12-12
How to Cite
1.
Inam B, Inam A, Verma M, Naik K, Alam A. Antidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat. ijpi [Internet]. 12Dec.2019 [cited 26Sep.2020];9(4):195-9. Available from: http://www.jpionline.org/index.php/ijpi/article/view/353