Fabricate and Characterization by Ionotropic Gelation Technology of the MicroBeads Loaded with Dicyclomine Hydrochloride for Gastroretentive Drug Delivery System

  • Kaushlendra Pratap Singh Department of Pharmaceutics, NKBR College of Pharmacy and Research Center, Meerut, Uttar Pradesh, INDIA.
  • Sachin Kumar Department of Pharmaceutics, NKBR College of Pharmacy and Research Center, Meerut, Uttar Pradesh, INDIA.
Keywords: MicroBeads, Gastroretentive Drug Delivery System, Dicyclomine Hydrochloride, Ionotropic gelation method, Bioavailability enhancement

Abstract

Objectives: The principal objective of this research is to fabricate, characterize and in vitro evaluation of floating gastroretentive Dicyclomine Hydrochloride beads. Methods: In this study, Ionotropic gelation technology was used to float gastro retentive Dicyclomine Hydrochloride beads. Subsequently, the floating properties, entrapment efficiency, in vitro release of beads were all determined during the characterization process. Results: The results showed concluded that formulation B11 have shown higher total floating time and lesser floating lag time values and a better drug release profile. Conclusion: Six formulations B3, B6, B9, B10, B11, and B12, met all of the requirements and features necessary for a successful floating formulation. For the preparations, all of the evaluation tests were completed. With changes in the ratio of sodium alginate and Hydroxypropyl Methylcellulose and the number of effervescent agents in the formulations, the formulations’ drug release pattern and floating capabilities were shown to be varied. The experiment and the results reveal that Dicyclomine Hydrochloride floating beads enhance stomach residence and bioavailability while decreasing the dosage and dosage interval.

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Published
2021-10-13
How to Cite
1.
Pratap Singh K, Kumar S. Fabricate and Characterization by Ionotropic Gelation Technology of the MicroBeads Loaded with Dicyclomine Hydrochloride for Gastroretentive Drug Delivery System. ijpi [Internet]. 13Oct.2021 [cited 16Oct.2021];11(3):283-7. Available from: http://www.jpionline.org/index.php/ijpi/article/view/1060