Users Online: 315 | Home Print this page Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL RESEARCH ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 4  |  Page : 192-199

Resveratrol attenuates malathion-induced renal damage by declining oxidative stress in rats


1 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Dr. Mohammad Reza Salahshoor
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jphi.JPHI_7_19

Rights and Permissions

Background: Malathion is the most organophosphates which are capable to produce free radicals and induce disturbance in body antioxidant. Resveratrol is an herbal polyphenol and it has been beneficial antioxidant effects during short-term administration. This study was designed to evaluate the effects of resveratrol against damage induced by malathion to the kidneys of rats. Materials and Methods: Forty-eight Wistar rats divided randomly into eight groups (n = 6): sham (saline) and malathion control treated groups (27 mg/kg); resveratrol groups (2, 8, and 20 mg/kg); and resveratrol + malathion-treated groups (2, 8, and 20 mg/kg). Treatments were administered intraperitoneally and gavage daily for 45 days. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples in respect of the groups. Results: Malathion administration increased significantly Bowman's space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to the Sham group (P < 0.001). The resveratrol and resveratrol + malathion treatments in a dose-dependent manner reduced significantly Bowman's space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to the malathion control group (P < 0.001). Conclusion: It seems that resveratrol administration in a dose-dependent manner improved kidney injury induced by malathion in rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed139    
    Printed2    
    Emailed0    
    PDF Downloaded31    
    Comments [Add]    

Recommend this journal