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Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 53-62

Usnic acid-loaded bioinspired heparin modified-cellulose acetate phthalate nanoparticle(s) as an efficient carrier for site-specific delivery in lung cancer cells

1 Department of Pharmaceutics, RKDF College of Pharmacy, SRK University, Bhopal, Madhya Pradesh, India
2 Department of Pharmaceutics, Drug Delivery and Nanotechnology Laboratories, Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh, India

Correspondence Address:
Dr. Awesh Kumar Yadav
Department of Pharmaceutics, Drug Delivery and Nanotechnology Laboratories, Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jphi.JPHI_5_18

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Introduction: The main goal of the current study was to assess the cytotoxic influence of usnic acid (UA) after enclosement in heparin modified-cellulose acetate phthalate (HEC) nanoparticles (NPs) when targeted to lung cancer A549 cell line. Materials and Methods: HEC copolymer was manufactured by precipitation method and was substantiated by Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. HEC NPs with UA was formulated by employing HEC copolymer and later competed with UA-loaded cellulose acetate phthalate (CAP) NPs. NPs were exemplified by zeta potential, differential scanning calorimetry, particle size, atomic force microscopy, in vitro release, entrapment efficiency, X-ray diffraction , and polydispersity index. Results: Studies revealed that HEC NPs have a slower release (96.21% in 32 h) when contrasted with CAP NPs (97.36% in 8 h). In cytotoxicity analysis of A549, UA-loaded HEC NPs illustrated an immense cytotoxic potential. In addition, HEC NPs were found to be more hemocompatable in comparison to CAP NPs and plain UA. Conclusion: Decisively, on account of investigational results UA-loaded HEC NPs were percieved to be more cytotoxic against lung cancer cells than UA-loaded CAP NPs and plain UA.

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