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ORIGINAL RESEARCH ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 7-13

Design and investigation of metformin hydrochloride–Indion-254 complex for dispersible tablets


1 Department of Pharmacology; School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago, West Indies
2 School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies; Laboratory of Pharmaceutical Formulation Design and Development, School of Pharmacy Faculty of Medical Sciences, St. Augustine, Trinidad and Tobago, West Indies
3 Department of Pharmacology, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
4 School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies

Correspondence Address:
Dr. Madan Mohan Gupta
School of Pharmacy, Faculty of Medical Sciences, Building 39, Eric Willaims Medical Sciences Complex, Mount Hope, The University of the West Indies, Trinidad and Tobago
West Indies
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jphi.JPHI_3_18

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Objective: Metformin is a first-line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion-254 resin for the purpose of preparation of dispersible tablet. Materials and Methods: This study formulated metformin hydrochloride–Indion-254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability. Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X-ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients. Conclusion: The formulated metformin hydrochloride–Indion-254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.


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