Users Online: 103 | Home Print this page Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
GUEST EDITORIAL
Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 53

Exploring delivery of nutraceuticals using nanotechnology


Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India

Date of Web Publication24-Aug-2012

Correspondence Address:
Jasjeet K Sahni
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-973X.100033

Rights and Permissions

How to cite this article:
Sahni JK. Exploring delivery of nutraceuticals using nanotechnology. Int J Pharma Investig 2012;2:53

How to cite this URL:
Sahni JK. Exploring delivery of nutraceuticals using nanotechnology. Int J Pharma Investig [serial online] 2012 [cited 2018 Sep 26];2:53. Available from: http://www.jpionline.org/text.asp?2012/2/2/53/100033

The term "nutraceuticals" given by founder and chairman of the foundation for innovative medicine, Stephen DeFelice in the early 1980s, is made up of two terms nutrition and Pharmaceuticals.  [1],[2] Nutraceuticals are defined as components/nutrients isolated or purified from foods which have health benefits besides their actual function of providing nutrition and are therefore used to prevent the occurrence of a disease or are used in its treatment. They are usually sold in medicinal forms not associated with the foods from which are derived/isolated.

The success of nutraceuticals can be attributed to their trait of imparting the desirable therapeutic benefits with a reduction in the side effects, associated with the use of pharmaceutical substances used in the prevention and treatment of various ailments.

Over the years, by doing appropriate experiments, researchers worldwide have proved beyond doubt that nutraceuticals provide protection against a number of diseases including cardiovascular diseases, cancer, diabetes, and even neurodegenerative disorders. Although the list of nutraceuticals used in the treatment of diseases is quite long, but over the past few years, phytochemicals with potential health and physiological benefits such as herbal polyphenols, to name a few curcumin, resveratrol, blueberry, rutin, and carotenoids like beta-carotene present in yellow, orange, and green vegetables and fruits have attracted researchers as well as consumers not only due to their ability to prevent and treat a number of diseases like cancers, cardiovascular disorders, and even neurodegenerative disorders like Alzheimer's disease due to their inherent antioxidant property but also due to their beneficial effects in improving the immunity.

However, the low bioavailability associated with a majority of the phytochemicals with health benefits either due to their poor solubility in the gastrointestinal fluids thereby leading to their incomplete absorption from the gastrointestinal tract or due their first pass metabolism, resulting in their diminished or no biological activity, is a major concern of the scientists today. In order to address this issue, principles of nanotechnology have been utilized by various researchers for the efficient delivery of these nutraceuticals with the aim to enhance their biological activity.

A number of formulation approaches like nanoemulsions, micelles, nanoparticles, nanocapsules, nanocochleats, nanocrystals, etc. have been utilized for the efficient delivery of the encapsulated nutraceutical. The developed nanoformulations provide a targeted delivery of the encapsulated phytochemical as well as its sustained release from the nanoformulation besides improving its bioavailability and hence therapeutic efficacy.

A good example to illustrate this is the tremendous improvement in the solubility and hence bioavailability of curcumin, a nutraceutical with anticancer potential which has been proved by various animal and cell culture models, by formulation of different nanoformulations like nanoparticles, micelles, and liposomes.

Although, scientists have successfully improved the bioavailability and therapeutic potential of various phytochemicals in vitro by formulating them as nanoformulations, extensive in vivo studies still need to be done to prove their efficacy. Besides this, the scientists and researchers should also ponder about the toxicity potential and safety aspects of these nanoencapsulated nutraceuticals to the human body as well as to the environment.

 
  References Top

1.Gupta S, Chauhan D, Mehla K, Sood P, Nair A. An overview of neutraceuticals: Current scenario. J Basic Clin Pharm 2010;1:55-62.  Back to cited text no. 1
    
2.Brower V. Nutraceuticals: Poised for a healthy slice of the healthcare market? Nat Biotechnol 1998;16:728-31.  Back to cited text no. 2
[PUBMED]    



This article has been cited by
1 In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin: Delineating the most suitable vesicular systems
Orchid Ashraf,Maha Nasr,Marianne Nebsen,Azza Mohamed Ahmed Said,Omaima Sammour
International Journal of Pharmaceutics. 2018;
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References

 Article Access Statistics
    Viewed1726    
    Printed182    
    Emailed0    
    PDF Downloaded438    
    Comments [Add]    
    Cited by others 1    

Recommend this journal