Users Online: 324 | Home Print this page Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 12-17

Improvement in solubility of poor water-soluble drugs by solid dispersion


Department of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India

Correspondence Address:
Swati Sareen
School of Pharmaceutical Sciences, Shoolini University, Village Bajhol, P.O. Sultanpur, Via Kumarhatti, Distt. Solan - 173 229, Himachal Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-973X.96921

Rights and Permissions

This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed6588    
    Printed182    
    Emailed0    
    PDF Downloaded1037    
    Comments [Add]    
    Cited by others 25    

Recommend this journal