Users Online: 117 | Home Print this page Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL RESEARCH ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 105-111

Formulation development and in vitro evaluation of gastroretentive hollow microspheres of famotidine


1 Department of Pharmaceutics, SNJB's Shriman Suresh Dada Jain College of Pharmacy, Neminagar, Chandwad, Nasik, Maharashtra, India
2 KK College of Pharmacy, Mangadu, Chennai, Tamil Nadu, India

Correspondence Address:
Mayur A Chordiya
SSDJ College of Pharmacy, Neminagar, Chandwad  -   423 101, Nasik, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-973X.82423

Rights and Permissions

Background: The main aim of this study was to develop a gastroretentive, multiple-unit floating drug delivery system for a drug which is poorly absorbed from the lower gastrointestinal tract. Such a dosage form may provide an extended retention of drug in the upper gastrointestinal tract resulting in enhanced absorption and improved bioavailability. Materials and Methods: Microspheres were prepared by the emulsion solvent diffusion method. Four different ratios (1:1, 1:2, 1:3, and 1:4) from each polymer, i.e., Eudragit RL 100 (E1-E4) and cellulose acetate (C1-C4) were prepared. Results: Hollow microspheres were characterized by particle size using optical microscopy. The in vitro release data obtained for the formulations E1-E4 and C1-C4 showed good entrapment efficiency, good percentage buoyancy, and prolonged drug release. The in vitro drug release showed the highest regression coefficient values for Higuchi's model, indicating diffusion to be the predominant mechanism of drug release. The surface and cross-sectional morphology of the formulations E1-A and C1-A were determined using scanning electron microscopy. Conclusions: Thus, prepared floating hollow microspheres of famotidine may prove to be potential candidates for the multiple-unit drug delivery device adaptable for any intragastric condition.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed13825    
    Printed223    
    Emailed2    
    PDF Downloaded1025    
    Comments [Add]    
    Cited by others 1    

Recommend this journal